{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:41:57Z","timestamp":1777920117985,"version":"3.51.4"},"reference-count":47,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1982,9,1]],"date-time":"1982-09-01T00:00:00Z","timestamp":399686400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1982,9]]},"abstract":"<jats:p>Twenty one- to two-month-old Holstein, Angus, or Holstein-Angus crossbred calves were given intravenous complete Freund's adjuvant and their lungs were examined at 24 hours to 30 days post-injection. Two calves given intravenous saline served as normal controls. The evolving pulmonary inflammatory response was characterized initially by multifocal vasculitis and acute multifocal exudative pneumonitis which progressed to a granulomatous interstitial pneumonitis by seven days post-injection. Discrete granulomas characterized the lesions in the lungs and lymph nodes at 30 days post-injection, and granulomas also were seen in liver, kidney, and spleen. Clinically, the calves were tachypneic and pyrexic during the first week post-injection. Four calves developed acute pulmonary edema and died during, or shortly after, administration of the adjuvant. This model of experimental pneumonia in calves is similar to complete Freund's adjuvant-induced experimental pneumonia in other species. It is reproducible and predictable in its course of development and resolution, and provides a useful model for studying basic mechanisms of pulmonary inflammatory injury and repair in the bovine lung.<\/jats:p>","DOI":"10.1177\/030098588201900506","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:20:28Z","timestamp":1268068828000},"page":"506-520","source":"Crossref","is-referenced-by-count":5,"title":["The Bovine Pulmonary Inflammatory Response: Adjuvant Pneumonitis in Calves"],"prefix":"10.1177","volume":"19","author":[{"given":"J. C.","family":"Lay","sequence":"first","affiliation":[{"name":"Department of Pathology, New York State College of Veterinary Medicine, Cornell University, Ithaca, N.Y."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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