{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T23:11:50Z","timestamp":1790118710120,"version":"4.0.1"},"reference-count":34,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:p>Two groups of three German shepherd dogs each were inoculated with Leishmania chagasi or Leishmania donovani amastigotes and the infection was followed for 82 days. The dogs developed a persistent infection, became thin, and developed splenomegaly and lymphadenomegaly by 55 days after inoculation. All dogs developed a normocytic, normochromic anemia of increasing severity. Thrombocytopenia and leukopenia occasionally occurred. Blood tryptophan levels were decreased significantly in infected dogs. Increased total serum protein, with hypergammaglobulinemia and hypoalbuminemia, was present in all dogs to various degrees. There was a marked increase in gamma globulins, with smaller increases in alpha and beta globulins. Many of the clinicopathologic changes observed in these dogs were similar to the disease as it occurs in man. The German shepherd dog may be a useful laboratory model for the study of visceral leishmaniasis.<\/jats:p>","DOI":"10.1177\/030098588402100113","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T16:50:33Z","timestamp":1484499033000},"page":"74-79","source":"Crossref","is-referenced-by-count":67,"title":["Visceral Leishmaniasis in the German Shepherd Dog. I. Infection, Clinical Disease, and Clinical Pathology"],"prefix":"10.1177","volume":"21","author":[{"given":"C. M.","family":"Keenan","sequence":"first","affiliation":[{"name":"Department of Comparative Pathology, Division of Pathology, Washington, D.C."},{"name":"Department of Parasitology, Division of Experimental Therapeutics, Washington, D.C."},{"name":"Department of Hematology, Division of Medicine, Washington, D.C."},{"name":"Walter Reed Army Institute of Research, Washington, D.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. D.","family":"Hendricks","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology, Division of Pathology, Washington, D.C."},{"name":"Department of Parasitology, Division of Experimental Therapeutics, Washington, D.C."},{"name":"Department of Hematology, Division of Medicine, Washington, D.C."},{"name":"Walter Reed Army Institute of Research, Washington, D.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Lightner","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology, Division of Pathology, Washington, D.C."},{"name":"Department of Parasitology, Division of Experimental Therapeutics, Washington, D.C."},{"name":"Department of Hematology, Division of Medicine, Washington, D.C."},{"name":"Walter Reed Army Institute of Research, Washington, D.C."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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J.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Comparative Pathology, Division of Pathology, Washington, D.C."},{"name":"Department of Parasitology, Division of Experimental Therapeutics, Washington, D.C."},{"name":"Department of Hematology, Division of Medicine, Washington, D.C."},{"name":"Walter Reed Army Institute of Research, Washington, D.C."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1984,1,1]]},"reference":[{"key":"bibr1-030098588402100113","unstructured":"Adler S.: Canine visceral leishmaniasis with special reference to its relationship to human visceral leishmaniasis.\n                      In\n                      : 3\n                      e\n                      Congres Internatinal de Pathologie Comparee, Sect. Med. 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