{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:43:11Z","timestamp":1777920191536,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1984,7,1]],"date-time":"1984-07-01T00:00:00Z","timestamp":457488000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1984,7]]},"abstract":"<jats:p>Five- to six-week-old crossbred pigs weighing 5 to 14 kg were given purified cyclopiazonic acid at dosages of 10, 1.0, 0.1, and 0.01 mg\/kg body weight orally for 14 days. Clinical signs observed by day 7 in pigs given 10 mg\/kg body weight were weakness, inactivity, anorexia, rough hair coats, and reduced body weights. These pigs also developed diarrhea during week 2 of the experiment. The pigs given 1.0 mg\/kg body weight had rough hair coats and were moderately inactive during the second week of the experiment. At necropsy, lesions were observed only in pigs given 10 and 1.0 mg\/kg body weight of cyclopiazonic acid. Lesions were gastric ulcers, mucosal hyperemia, and hemorrhage throughout the small and large intestine in pigs given 10 mg\/kg body weight of cyclopiazonic acid. The pigs also had yellow, fibrinonecrotic material in the lumen of the small intestine and pale livers. One pig given 1.0 mg\/kg body weight had gastric ulceration. Microscopic lesions in pigs given 10 mg\/kg body weight were necrotizing gastroenteritis, focal hepatocellular necrosis, hepatic peripheral lobular fatty change, and focal renal tubular nephrosis with focal suppurative tubulointerstitial nephritis. Pigs given 1.0 mg\/kg body weight of cyclopiazonic acid had necrotizing gastritis and villous blunting in the jejunum and ileum.<\/jats:p>","DOI":"10.1177\/030098588402100408","type":"journal-article","created":{"date-parts":[[2017,1,18]],"date-time":"2017-01-18T02:14:06Z","timestamp":1484705646000},"page":"418-424","source":"Crossref","is-referenced-by-count":57,"title":["The Toxicity of Cyclopiazonic Acid in Weaned Pigs"],"prefix":"10.1177","volume":"21","author":[{"given":"L. G.","family":"Lomax","sequence":"first","affiliation":[{"name":"Veterinary Diagnostic and Investigational Laboratory, University of Georgia, Tifton, GA and National Peanut Research Laboratory, USDA, ARS, Dawson, GA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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