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Transient improvement is followed by deterioration and progressive spastic paraplegia. Generalized tremors can be induced easily by a variety of stimuli, and spinal reflexes may be exaggerated or depressed. The major pathological finding is an excessive accumulation of neurofilaments within neurons of the central, peripheral, and autonomic nervous systems. The involvement of multiple systems of neurons and the similarity with some forms of human motor neuron disease and spinocerebellar degeneration suggest that this unique bovine disease may serve as a suitable animal model for these human neurodegenerative disorders.<\/jats:p>","DOI":"10.1177\/030098588502200202","type":"journal-article","created":{"date-parts":[[2017,1,15]],"date-time":"2017-01-15T13:39:15Z","timestamp":1484487555000},"page":"104-111","source":"Crossref","is-referenced-by-count":26,"title":["\u201cShaker\u201d Calf Syndrome: A Newly Recognized Inherited Neurodegenerative Disorder of Horned Hereford Calves"],"prefix":"10.1177","volume":"22","author":[{"given":"C. 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G.","family":"Klavano","sequence":"additional","affiliation":[{"name":"Department of Pathology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Alberta Department of Agriculture, Animal Health Division, Pathology Branch, Edmonton, Alberta, Canada; Department of Pathology, University of Alberta, Canada; Alberta Department of Agriculture, Animal Health Division, Lethbridge, Alberta, Canada; and Department of Medical Biochemistry, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E. 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