{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:44:11Z","timestamp":1777920251225,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1986,1,1]],"date-time":"1986-01-01T00:00:00Z","timestamp":504921600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1986,1]]},"abstract":"<jats:p>Rhinosporidiosis was diagnosed in six dogs from the southeastern United States. All six dogs had unilateral nasal polyps with multiple small white sporangia visible beneath the surface. Microscopically, the polyps consisted of organisms and fibrovascular tissue with a surface of columnar or squamous epithelium. Juvenile sporangia were unilamellar, 15-75 in diameter, nucleated, and accounted for about 65% of sporangia seen. Approximately 5% of the sporangia were in intermediate stages of maturation, were bilamellar, 100-150 \u03bcm in diameter, and contained immature endospores. Mature sporangia comprised about 30% of the total, were usually unilamellar, 100-400 \u03bcm in diameter, and contained a mixture of immature and mature endospores.<\/jats:p>\n                  <jats:p>\n                    The inner layer of the wall of the intermediate sporangia and the single wall of the mature sporangia were argyrophilic and carminophilic. Ultrastructurally. the earliest stage contained a nucleus and many ribosomes, lipid droplets, and phagolysosomes. Maturing sporangia contained discrete membrane-bound, round clevage products. These structures subsequently matured to spores, each of which had a wall and contained a nucleus and many lipid droplets. The organism from one dog was cultured and grown in vitro for 7 months and is the first successful cultivation of\n                    <jats:italic toggle=\"yes\">Rhinosporidium seeberi.<\/jats:italic>\n                  <\/jats:p>","DOI":"10.1177\/030098588602300108","type":"journal-article","created":{"date-parts":[[2017,1,17]],"date-time":"2017-01-17T23:34:28Z","timestamp":1484696068000},"page":"50-56","source":"Crossref","is-referenced-by-count":28,"title":["Nasal Rhinosporidiosis in the Dog"],"prefix":"10.1177","volume":"23","author":[{"given":"J. R.","family":"Easley","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. J.","family":"Meuten","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Levy","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Dykstra","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. B.","family":"Breitschwerdt","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. A.","family":"Holzinger","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. C.","family":"Cattley","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine. North Carolina State University, Raleigh, NC"},{"name":"Western Animal Disease Diagnostic Laboratory. Arden, NC"},{"name":"University of North Carolina. Chapel Hill, NC"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,1]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S008045680000404X"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00548922"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1977.171.09.989"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02053118"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/00362177085190451"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/82.5.611"},{"key":"e_1_2_1_8_1","first-page":"672","volume-title":"Veterinary Pathology","author":"Jones TC","year":"1983","unstructured":"Jones TC, Hunt RD: Veterinary Pathology, p. 672. Lea and Febiger, Philadelphia. 1983"},{"key":"e_1_2_1_9_1","first-page":"51","article-title":"Rhinosporidium seeberi. An ultrastructural study of its endosporulation phase and trophocyte phase.","volume":"99","author":"Kannan-Kutty M","year":"1975","unstructured":"Kannan-Kutty M, Teh EC: Rhinosporidium seeberi. An ultrastructural study of its endosporulation phase and trophocyte phase. Arch Pathol 99: 51. 1975","journal-title":"Arch Pathol"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313027409077157"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-196312000-00008"},{"key":"e_1_2_1_12_1","unstructured":"Levy MG Meuten DJ Breitschwerdt EB: In vitro cultivation of Rhinosporidium seeberi. Submitted for publication"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00448411"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1984.185.09.1009"},{"key":"e_1_2_1_15_1","first-page":"345","article-title":"Rhinosporidiosis in a horse.","volume":"145","author":"Myers DD","year":"1964","unstructured":"Myers DD, Simon J, Case MT: Rhinosporidiosis in a horse. J Am Vet Med Assoc 145: 345. 1964","journal-title":"J Am Vet Med Assoc"},{"key":"e_1_2_1_16_1","first-page":"325","volume-title":"Medical Mycology.","author":"Rippon JW","year":"1982","unstructured":"Rippon JW: Medical Mycology. 2nd ed., p. 325. WB Saunders Co., Philadelphia, 1982","edition":"2"},{"key":"e_1_2_1_17_1","first-page":"22","article-title":"Rhinosporidiosis in a Texas horse.","volume":"15","author":"Smith HA","year":"1961","unstructured":"Smith HA, Frankson MC: Rhinosporidiosis in a Texas horse. Southwest Vet 15: 22, 1961","journal-title":"Southwest Vet"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1975.167.10.941"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/00313027509092709"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/52.4.1101"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1973.tb00208.x"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588602300108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588602300108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:25:00Z","timestamp":1777663500000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588602300108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1986,1]]}},"alternative-id":["10.1177\/030098588602300108"],"URL":"https:\/\/doi.org\/10.1177\/030098588602300108","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,1]]}}}