{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:44:36Z","timestamp":1777920276011,"version":"3.51.4"},"reference-count":20,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1986,7,1]],"date-time":"1986-07-01T00:00:00Z","timestamp":520560000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1986,7]]},"abstract":"<jats:p>\n                    Twenty pigs were fed a diet containing 187.5 mg kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    of 3-nitro-4-hydroxyphenylarsonic acid (3-nitro). Ten pigs were euthanized at intervals up to 29 days, 3-nitro was withdrawn from the diet of the remaining pigs on day 30, and these animals were subsequently euthanized at intervals up to 49 days after commencement of the experiment. A nervous syndrome characterized by clonic convulsive episodes inducible by exercise, developed at day 11. Paraparesis was apparent at day 22 progressing to paraplegia by day 33 (3 days after cessation of 3-nitro feeding). Histopathologic examination revealed myelin and axonal degeneration in the white matter of the spinal cord coincident with the onset of nervous signs. Marchi-positive degeneration was present in the dorsal funiculus at cervical level at day 22. Lesions intensified with increasing duration of toxicosis and while degenerate fibers were seen in all funiculi, there was preferential involvement of the fasciculi gracilis and cuneatus, the peripheral regions of the ventral and lateral funiculi, and a discrete area of the dorsal region of the lateral funiculus. Peripheral and optic neuropathies were evident from day 32 but were always mild and focal. The experiment establishes 3-nitro as a central-peripheral neurotoxicant of pigs.\n                  <\/jats:p>","DOI":"10.1177\/030098588602300416","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:19:57Z","timestamp":1268068797000},"page":"454-461","source":"Crossref","is-referenced-by-count":15,"title":["Neuropathology of Experimental 3-nitro-4-hydroxyphenylarsonic Acid Toxicosis in Pigs"],"prefix":"10.1177","volume":"23","author":[{"given":"S.","family":"Kennedy","sequence":"first","affiliation":[{"name":"Departments of Pathology and Biochemistry, Veterinary Research Laboratories, Stoney Road, Stormont, Belfast BT4 3SD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Rice","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Biochemistry, Veterinary Research Laboratories, Stoney Road, Stormont, Belfast BT4 3SD"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. F.","family":"Cush","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Biochemistry, Veterinary Research Laboratories, Stoney Road, Stormont, Belfast BT4 3SD"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,7]]},"reference":[{"key":"e_1_2_2_2_2","unstructured":"Buck WB: Untoward reactions encountered with medicated feeds. In: Use of Drugs in Animal Feeds p. 196. Publ 1979 Nat Acad Sci Washington DC 1969."},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.2527\/jas1955.142435x"},{"key":"e_1_2_2_4_2","first-page":"37","article-title":"Attempts to determine tracts of the spinal cord in the pig by the use of the degeneration method. Ann Univ M","volume":"16","author":"Chomiak M","year":"1961","unstructured":"Chomiak M, Lewandowski M, Lutnicki W, Milart Z: Attempts to determine tracts of the spinal cord in the pig by the use of the degeneration method. Ann Univ M. 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J Anim Sci 21: 1014, 1962.","journal-title":"J Anim Sci"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.19.2.74"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.3109\/10520293509116018"},{"key":"e_1_2_2_20_2","doi-asserted-by":"publisher","DOI":"10.1136\/vr.105.12.276"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)33732-9"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588602300416","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588602300416","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:25:44Z","timestamp":1777663544000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588602300416"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1986,7]]}},"alternative-id":["10.1177\/030098588602300416"],"URL":"https:\/\/doi.org\/10.1177\/030098588602300416","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,7]]}}}