{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:44:44Z","timestamp":1777920284167,"version":"3.51.4"},"reference-count":46,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[1986,9,1]],"date-time":"1986-09-01T00:00:00Z","timestamp":525916800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1986,9]]},"abstract":"<jats:p>C57BL\/6N mice were treated to induce tolerance, to modulate the mixed function oxidase system or to deplete glutathione (GSH) before injection with 400 mg 3-methylindole (3MI)\/kg. Effect of pretreatment was determined by histologic comparison of pulmonary and nasal lesions 24 hours after 3 MI. \u03b2-Naphthoflavone and 3MI pretreatment significantly decreased 3MI-induced bronchiolar epithelial damage in male and female mice, while phenobarbital protection was significant only in female mice. Only \u03b2-naphthoflavone decreased nasal olfactory epithelial damage. Pretreatment with piperonyl butoxide, SKF 525-A, or \u03b1-naphthoflavone had no significant effect on development of lesions. Diethylmaleate pretreatment significantly increased mortality and bronchiolar damage in both sexes. Significant differences between male and female mice were not detected in any group. The results suggest that pretreatment with low doses of 3MI or induction of cytochrome P-448 or P-450 protects against 3MI toxicosis while GSH depletion increases mortality and pulmonary lesions.<\/jats:p>","DOI":"10.1177\/030098588602300504","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T09:17:10Z","timestamp":1484212630000},"page":"563-570","source":"Crossref","is-referenced-by-count":28,"title":["Chemical Modulation of 3-Methylindole Toxicosis in Mice: Effect on Bronchiolar and Olfactory Mucosal Injury"],"prefix":"10.1177","volume":"23","author":[{"given":"M. A. M.","family":"Turk","sequence":"first","affiliation":[{"name":"Departments of Veterinary Pathology, Veterinary Physiology, Pharmacology and Toxicology, Veterinary Anatomy and Fine Structure, and Veterinary Science, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Flory","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathology, Veterinary Physiology, Pharmacology and Toxicology, Veterinary Anatomy and Fine Structure, and Veterinary Science, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. G.","family":"Henk","sequence":"additional","affiliation":[{"name":"Departments of Veterinary Pathology, Veterinary Physiology, Pharmacology and Toxicology, Veterinary Anatomy and Fine Structure, and Veterinary Science, Louisiana State University, Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1986,9]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"433","article-title":"Ultrastructural pathology of 3-methylindole-induced pneumotoxicity in cattle. I. Glycogen accumulation in the alveolar type II cells and tubular myelin accumulation in the alveoli.","volume":"15","author":"Atwal OS","year":"1983","unstructured":"Atwal OS: Ultrastructural pathology of 3-methylindole-induced pneumotoxicity in cattle. I. Glycogen accumulation in the alveolar type II cells and tubular myelin accumulation in the alveoli. J Submicrosc Cytol 15: 433, 1983","journal-title":"J Submicrosc Cytol"},{"key":"e_1_2_2_3_1","first-page":"132","article-title":"Hepatotoxicity produced by the lung-toxic furanoterpenoid, 4-ipomeanol, after mixed-function oxidase induction: reversal of target organ for toxicity and covalent binding in rats pretreated with 3-methylcholanthrene.","volume":"33","author":"Boyd MR","year":"1975","unstructured":"Boyd MR: Hepatotoxicity produced by the lung-toxic furanoterpenoid, 4-ipomeanol, after mixed-function oxidase induction: reversal of target organ for toxicity and covalent binding in rats pretreated with 3-methylcholanthrene. Toxicol Appl Pharmacol 33: 132, 1975","journal-title":"Toxicol Appl Pharmacol"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/269713a0"},{"key":"e_1_2_2_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408448009037487"},{"key":"e_1_2_2_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(81)90091-3"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)31469-2"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/272270a0"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)31922-1"},{"key":"e_1_2_2_10_1","first-page":"551","article-title":"Ultrastructural pulmonary changes induced by intravenously administered 3-methylindole in goats.","volume":"99","author":"Bradley BJ","year":"1980","unstructured":"Bradley BJ, Carlson JR: Ultrastructural pulmonary changes induced by intravenously administered 3-methylindole in goats. Am J Pathol 99: 551, 1980","journal-title":"Am J Pathol"},{"key":"e_1_2_2_11_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1978.39.08.1355"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1979.40.09.1268"},{"key":"e_1_2_2_13_1","first-page":"1329","article-title":"Covalent binding of 3-methylin-dole metabolites in goat lung microsomal preparations.","volume":"38","author":"Bray TM","year":"1979","unstructured":"Bray TM, Carlson JR: Covalent binding of 3-methylin-dole metabolites in goat lung microsomal preparations. Fed Proc 38: 1329, 1979","journal-title":"Fed Proc"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-176-41841"},{"key":"e_1_2_2_15_1","doi-asserted-by":"publisher","DOI":"10.21423\/bovine-vol1978no13p75-81"},{"key":"e_1_2_2_16_1","first-page":"137","article-title":"Effect of rumen development and pre-exposure to chemicals on the activity of the mixed function oxidase system in goats.","volume":"75","author":"Burley FE","year":"1983","unstructured":"Burley FE, Bray TM: Effect of rumen development and pre-exposure to chemicals on the activity of the mixed function oxidase system in goats. Comp Biochem Physiol 75C: 137, 1983","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1515\/9783111641546-068"},{"key":"e_1_2_2_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.176.4032.298"},{"key":"e_1_2_2_19_1","first-page":"128","article-title":"Pulmonary lesions induced by 3-methylindole in mice.","volume":"121","author":"Durham SK","year":"1985","unstructured":"Durham SK, Castleman WL: Pulmonary lesions induced by 3-methylindole in mice. Am J Pathol 121: 128, 1985","journal-title":"Am J Pathol"},{"key":"e_1_2_2_20_1","doi-asserted-by":"publisher","DOI":"10.3109\/01902148209115816"},{"key":"e_1_2_2_21_1","first-page":"388","article-title":"Studies on the mechanism of glutathione prevention of carbon tetrachloride-induced liver injury.","volume":"64","author":"Gorla N","year":"1983","unstructured":"Gorla N, De Ferreyra EC, Villarruel MC, De Fenos OM, Castro JA: Studies on the mechanism of glutathione prevention of carbon tetrachloride-induced liver injury. Br J Exp Pathol 64: 388, 1983","journal-title":"Br J Exp Pathol"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)33093-4"},{"key":"e_1_2_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(81)90408-7"},{"key":"e_1_2_2_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-9556(25)08017-1"},{"key":"e_1_2_2_25_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1979.40.10.1398"},{"key":"e_1_2_2_26_1","first-page":"306","article-title":"Factors affecting binding of 3-methylindole metabolites in crude microsomal preparations.","volume":"39","author":"Hammond AC","year":"1980","unstructured":"Hammond AC, Breeze RG, Carlson JR: Factors affecting binding of 3-methylindole metabolites in crude microsomal preparations. Fed Proc 39: 306, 1980","journal-title":"Fed Proc"},{"key":"e_1_2_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(80)90476-2"},{"key":"e_1_2_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(84)90256-4"},{"key":"e_1_2_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(83)90063-1"},{"key":"e_1_2_2_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4274(82)90013-3"},{"key":"e_1_2_2_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)33722-5"},{"key":"e_1_2_2_32_1","first-page":"647","article-title":"3-Methylindole-induced pulmonary injury in goats.","volume":"87","author":"Huang TW","year":"1977","unstructured":"Huang TW, Carlson JR, Bray TM, Bradley BJ: 3-Methylindole-induced pulmonary injury in goats. Am J Pathol 87: 647, 1977","journal-title":"Am J Pathol"},{"key":"e_1_2_2_33_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498258409151402"},{"key":"e_1_2_2_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)91609-1"},{"key":"e_1_2_2_35_1","doi-asserted-by":"publisher","DOI":"10.1139\/y83-060"},{"key":"e_1_2_2_36_1","first-page":"395","article-title":"Effects of species, MFO inducers and conjugation agents on the in vitro covalent binding of 14C-3-methylindole metabolite in liver and lung tissues.","volume":"75","author":"Merrill JC","year":"1983","unstructured":"Merrill JC, Bray TM: Effects of species, MFO inducers and conjugation agents on the in vitro covalent binding of 14C-3-methylindole metabolite in liver and lung tissues. Comp Biochem Physiol 75C: 395, 1983","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_2_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/113.9.1725"},{"key":"e_1_2_2_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(84)90091-X"},{"key":"e_1_2_2_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90137-6"},{"key":"e_1_2_2_40_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8455359"},{"key":"e_1_2_2_41_1","first-page":"51","volume-title":"Reviews in Biochemical Toxicology","author":"Philpot RM","year":"1981","unstructured":"Philpot RM, Wolf CR: The properties and distribution of the enzymes of pulmonary cytochrome P-450-dependent monooxygenase systems. In: Reviews in Biochemical Toxicology, ed. Hodgson E, Bend JR, Philpot RM, vol. 3, p. 51. Elsevier\/North Holland, New York, 1981"},{"key":"e_1_2_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(79)90030-5"},{"key":"e_1_2_2_43_1","first-page":"209","article-title":"Pathologic changes in 3-methylindole-induced equine bronchiolitis.","volume":"110","author":"Turk MAM","year":"1983","unstructured":"Turk MAM, Breeze RG, Gallina AM: Pathologic changes in 3-methylindole-induced equine bronchiolitis. Am J Pathol 110: 209, 1983","journal-title":"Am J Pathol"},{"key":"e_1_2_2_44_1","first-page":"351","article-title":"Dose response in 3-methylindole-induced bronchiolar epithelial necrosis in mice.","volume":"46","author":"Turk MAM","year":"1984","unstructured":"Turk MAM, Flory W, Henk WG: Dose response in 3-methylindole-induced bronchiolar epithelial necrosis in mice. Res Comm Chem Pathol Pharmacol 46: 351, 1984","journal-title":"Res Comm Chem Pathol Pharmacol"},{"key":"e_1_2_2_45_1","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.1986.47.04.901"},{"key":"e_1_2_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-2797(82)90152-1"},{"key":"e_1_2_2_47_1","first-page":"327","article-title":"Acute respiratory distress syndrome occurring in Texas pastured cattle.","volume":"20","author":"Williams GH","year":"1977","unstructured":"Williams GH, Hatkin J, Jones LP: Acute respiratory distress syndrome occurring in Texas pastured cattle. Proc Amer Assoc Vet Lab Diagnosticians 20: 327, 1977","journal-title":"Proc Amer Assoc Vet Lab Diagnosticians"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588602300504","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588602300504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:25:56Z","timestamp":1777663556000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588602300504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,9]]},"references-count":46,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1986,9]]}},"alternative-id":["10.1177\/030098588602300504"],"URL":"https:\/\/doi.org\/10.1177\/030098588602300504","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1986,9]]}}}