{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:45:01Z","timestamp":1777920301877,"version":"3.51.4"},"reference-count":66,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1987,3,1]],"date-time":"1987-03-01T00:00:00Z","timestamp":541555200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:p>\n                    The in vivo infection of neonatal dogs by the microsporidian protozoan parasite,\n                    <jats:italic toggle=\"yes\">Encephalitozoon cuniculi<\/jats:italic>\n                    , was studied. Microscopic examination of tissues from infected animals showed granulomatous nephritis, meningoencephalitis, hepatitis, and pneumonitis. A large component of the inflammatory infiltrate consisted of plasma cells and lymphocytes. In addition, hyperplasia of B-lymphocyte-dependent regions of lymph nodes and erythrophagocytosis were consistently seen in infected dogs. Infected dogs developed lymphocytosis, hypergammaglobulinemia, anti-encephalitozoon antibodies, and an antigen-specific blastogenic response to\n                    <jats:italic toggle=\"yes\">E. cuniculi<\/jats:italic>\n                    spores. Lymphocyte blastogenic responses to the lectin phytohemagglutinin A (PHA) were depressed compared to controls. Dogs dying during the 2-month experimental trial were bacteremic. The findings of these experiments suggest that postnatal infection results in a demonstrable although seemingly ineffective immune and inflammatory response without detectable clinical disease.\n                  <\/jats:p>","DOI":"10.1177\/030098588702400201","type":"journal-article","created":{"date-parts":[[2017,1,20]],"date-time":"2017-01-20T22:18:20Z","timestamp":1484950700000},"page":"99-108","source":"Crossref","is-referenced-by-count":23,"title":["Experimental Encephalitozoonosis in Neonatal Dogs"],"prefix":"10.1177","volume":"24","author":[{"given":"J. R.","family":"Szabo","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathobiology, College of Veterinary Medicine University of Illinois, Urbana, IL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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