{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:28:01Z","timestamp":1791606481888,"version":"4.3.4"},"reference-count":44,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p>Liver tissues from 126 captive cheetah were evaluated by light microscopy and histochemistry; eight animals were evaluated by electron microscopy. The main hepatic lesion, a vascular lesion resembling veno-occlusive disease (VOD) of the liver and characterized by subendothelial fibrosis and proliferation of smooth muscle-like cells in the central veins, was seen in 60% of the sexually mature cheetah. Although this hepatic vascular lesion was seen in cheetah as young as 1 year of age, the most severe lesions, usually associated with liver failure, were found in cheetah between the ages of 6 and 11. There was no sex predisposition, and in approximately 40% of the VOD cases, liver disease was not suspected clinically or at necropsy. VOD was found in other felidae, especially in the snow leopard. High levels of vitamin A in livers, as well as in diets of the cheetah, could be a contributing factor in the development of VOD in some groups of cheetah.<\/jats:p>","DOI":"10.1177\/030098588802500107","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T17:39:07Z","timestamp":1264527547000},"page":"48-57","source":"Crossref","is-referenced-by-count":30,"title":["Veno-occlusive Disease of the Liver in Captive Cheetah"],"prefix":"10.1177","volume":"25","author":[{"given":"S. J.","family":"Gosselin","sequence":"first","affiliation":[{"name":"Merrell-Dow Research Institute and Cincinnati Zoo, Cincinnati"},{"name":"Department of Veterinary Pathobiology, The Ohio State University, Columbus"},{"name":"Department of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati"},{"name":"Kings Island Wild Animal Habitat, Kings Island;"},{"name":"Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. L.","family":"Loudy","sequence":"additional","affiliation":[{"name":"Merrell-Dow Research Institute and Cincinnati Zoo, Cincinnati"},{"name":"Department of Veterinary Pathobiology, The Ohio State University, Columbus"},{"name":"Department of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati"},{"name":"Kings Island Wild Animal Habitat, Kings Island;"},{"name":"Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. J.","family":"Tarr","sequence":"additional","affiliation":[{"name":"Merrell-Dow Research Institute and Cincinnati Zoo, Cincinnati"},{"name":"Department of Veterinary Pathobiology, The Ohio State University, Columbus"},{"name":"Department of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati"},{"name":"Kings Island Wild Animal Habitat, Kings Island;"},{"name":"Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. F.","family":"Balistreri","sequence":"additional","affiliation":[{"name":"Merrell-Dow Research Institute and Cincinnati Zoo, Cincinnati"},{"name":"Department of Veterinary Pathobiology, The Ohio State University, Columbus"},{"name":"Department of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati"},{"name":"Kings Island Wild Animal Habitat, Kings Island;"},{"name":"Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. D. 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L.","family":"Dresser","sequence":"additional","affiliation":[{"name":"Merrell-Dow Research Institute and Cincinnati Zoo, Cincinnati"},{"name":"Department of Veterinary Pathobiology, The Ohio State University, Columbus"},{"name":"Department of Pediatric Gastroenterology and Nutrition, Children's Hospital Medical Center, Cincinnati"},{"name":"Kings Island Wild Animal Habitat, Kings Island;"},{"name":"Department of Obstetrics and Gynecology, University of Cincinnati, Cincinnati, OH"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1988,1]]},"reference":[{"key":"e_1_2_2_2_1","first-page":"938","article-title":"The effect of estrogen on the vascular endothelium and its possible relation to thrombosis","volume":"140","author":"Almen T","year":"1975","unstructured":"1 Almen T, Hartel M, Nylander G, Olivecrona H: The effect of estrogen on the vascular endothelium and its possible relation to thrombosis. 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