{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T07:26:13Z","timestamp":1782631573363,"version":"3.54.5"},"reference-count":21,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:p>\n                    Bone marrow core biopsies from 63 dogs with malignant lymphoproliferative disorders and leukemic involvement were evaluated. Multicentric lymphoma (44), multiple myeloma (8), chronic lymphocytic leukemia (9), and acute lymphoblastic leukemia (2) were found. Four distinct bone marrow histologic patterns were identified:\n                    <jats:italic toggle=\"yes\">focal<\/jats:italic>\n                    (6),\n                    <jats:italic toggle=\"yes\">mixed<\/jats:italic>\n                    (20),\n                    <jats:italic toggle=\"yes\">interstitial<\/jats:italic>\n                    (28), and\n                    <jats:italic toggle=\"yes\">packed<\/jats:italic>\n                    (9). Of those with focal or mixed patterns, 77% (20\/26) had paratrabecular distribution. Stromal changes were infrequent, with 6% (4\/63) having necrosis, 3% (2\/63) fibrosis, and 6% (4\/63) osteolysis. For each condition, the interstitial and mixed patterns were the most common presentations, while focal and packed patterns occurred less frequently. Morphologically, cells of metastatic lesions of lymphoma resembled those of primary sites. Colonization of bone marrow by various cytologic types of lymphoma was independent of the histologic patterns.\n                  <\/jats:p>","DOI":"10.1177\/030098588802500112","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T17:39:07Z","timestamp":1264527547000},"page":"83-88","source":"Crossref","is-referenced-by-count":21,"title":["Histopathology of Canine Bone Marrow in Malignant Lymphoproliferative Disorders"],"prefix":"10.1177","volume":"25","author":[{"given":"R. E.","family":"Raskin","sequence":"first","affiliation":[{"name":"Department of Pathology, Michigan State University, East Lansing, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Krehbiel","sequence":"additional","affiliation":[{"name":"Department of Pathology, Michigan State University, East Lansing, MI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1988,1]]},"reference":[{"key":"e_1_2_2_2_1","volume-title":"Bone Marrow Biopsies Revisited: A New Dimension for Haematologic Malignancies","author":"Bartl R","year":"1985","unstructured":"1 Bartl R, Frisch B, Burkhardt R: Bone Marrow Biopsies Revisited: A New Dimension for Haematologic Malignancies, 2nd ed. Karger, Basel, 1985.","edition":"2"},{"key":"e_1_2_2_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1982.tb07284.x"},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.37.3.233"},{"key":"e_1_2_2_5_1","first-page":"154","article-title":"The cytology, histology and prevalence of cell types in canine lymphoma classified according to the National Cancer Institute Working Formulation","volume":"50","author":"Carter RF","year":"1986","unstructured":"4 Carter RF, Valli VEO, Lumsden JH: The cytology, histology and prevalence of cell types in canine lymphoma classified according to the National Cancer Institute Working Formulation. Can J Vet Res 50: 154\u2013164, 1986.","journal-title":"Can J Vet Res"},{"key":"e_1_2_2_6_1","first-page":"159","article-title":"Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: I. Treatment of dogs","volume":"19","author":"Cotter SM","year":"1983","unstructured":"5 Cotter SM: Treatment of lymphoma and leukemia with cyclophosphamide, vincristine, and prednisone: I. Treatment of dogs. J Am Anim Hosp Assoc 19: 159\u2013165, 1983.","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_2_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.1091680105"},{"key":"e_1_2_2_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.6.1417.1417"},{"key":"e_1_2_2_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02899.x"},{"key":"e_1_2_2_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/86.4.449"},{"key":"e_1_2_2_11_1","first-page":"909","article-title":"Canine bone marrow: normal hematopoiesis, biopsy techniques, and cell identification and evaluation","volume":"10","author":"Harvey JW","year":"1984","unstructured":"10 Harvey JW: Canine bone marrow: normal hematopoiesis, biopsy techniques, and cell identification and evaluation. Compend Contin Educ Pract Vet 10: 909\u2013926, 1984.","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_2_12_1","first-page":"34","article-title":"An appraisal of bone marrow biopsy in assessment of sick dogs","volume":"49","author":"Hoff B","year":"1985","unstructured":"11 Hoff B, Lumsden JH, Valli VEO: An appraisal of bone marrow biopsy in assessment of sick dogs. Can J Comp Med 49: 34\u201342, 1985.","journal-title":"Can J Comp Med"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/56.1.125"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1983.tb02276.x"},{"key":"e_1_2_2_15_1","first-page":"109","volume-title":"Bone Marrow Biopsy","author":"Krause JR","year":"1981","unstructured":"14 Krause JR: Bone Marrow Biopsy, pp. 109\u2013143. Churchill Livingstone, New York, 1981."},{"key":"e_1_2_2_16_1","volume-title":"Bone Marrow Evaluation in Veterinary Practice","author":"Lewis HB","year":"1979","unstructured":"15 Lewis HB, Rebar AH: Bone Marrow Evaluation in Veterinary Practice. Ralston Purina Co, St. Louis, 1979."},{"key":"e_1_2_2_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800915)46:6<1422::AID-CNCR2820460623>3.0.CO;2-B"},{"key":"e_1_2_2_18_1","first-page":"235","article-title":"Hematological and bone marrow cytological abnormalities in 75 dogs with malignant lymphoma","volume":"22","author":"Madewell BR","year":"1986","unstructured":"17 Madewell BR: Hematological and bone marrow cytological abnormalities in 75 dogs with malignant lymphoma. J Am Anim Hosp Assoc 22: 235\u2013240, 1986.","journal-title":"J Am Anim Hosp Assoc"},{"key":"e_1_2_2_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1985.tb01560.x"},{"key":"e_1_2_2_20_1","first-page":"83","volume-title":"Pathology of Domestic Animals","author":"Valli VEO","year":"1985","unstructured":"19 Valli VEO: The hematopoietic system. In: Pathology of Domestic Animals, ed. Jubb KVF, Kennedy PC, Palmer N, 3rd ed., pp. 83\u2013236. Academic Press, Orlando, 1985.","edition":"3"},{"key":"e_1_2_2_21_1","first-page":"91","article-title":"The mechanism of inhibition of haemopoiesis in acute leukemia","volume":"7","author":"van Bekkum DW","year":"1981","unstructured":"20 van Bekkum DW, Prins MEF, Hagenbeek A: The mechanism of inhibition of haemopoiesis in acute leukemia. Blood Cells 7: 91\u2013103, 1981.","journal-title":"Blood Cells"},{"key":"e_1_2_2_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1939-165X.1986.tb00636.x"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588802500112","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588802500112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:27:29Z","timestamp":1777663649000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588802500112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1177\/030098588802500112"],"URL":"https:\/\/doi.org\/10.1177\/030098588802500112","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}