{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:45:51Z","timestamp":1777920351684,"version":"3.51.4"},"reference-count":30,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1988,5]]},"abstract":"<jats:p>Male and female Wistar rats 2 to 15 months of age were inoculated intranasally with sialodacryoadenitis (SDA) virus and killed at 8 to 21 days post-inoculation (PI). Submandibular glands were evaluated by light and electron microscopy, and levels of salivary gland epidermal growth factor (EGF) were quantitated by cytochemistry and competitive radioreceptor assay. Apical granules in the epithelial cells of the granular convoluted tubules (GCT) were selectively depleted during the acute and convalescent stages of the disease. In addition, levels of immunoreactive EGF were reduced in affected submandibular glands, especially at 8 to 14 days PI with SDA virus, but some evidence of EGF depletion was seen at up to 3 weeks PI. A corresponding transient depletion of EGF receptor reactive salivary EGF was seen between 1 and 3 weeks after experimental SDA infection. These studies suggest that a clinical (or subclinical) infection with SDA virus could have significant effects on experimental studies on EGF-dependent functions, including reproductive physiology and carcinogenesis.<\/jats:p>","DOI":"10.1177\/030098588802500301","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T18:43:26Z","timestamp":1264531406000},"page":"183-192","source":"Crossref","is-referenced-by-count":21,"title":["Depletion of Salivary Gland Epidermal Growth Factor by Sialodacryoadenitis Virus Infection in the Wistar Rat"],"prefix":"10.1177","volume":"25","author":[{"given":"D. H.","family":"Percy","sequence":"first","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, University of Guelph, Guelph; and Warner Lambert Laboratories, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. A.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, University of Guelph, Guelph; and Warner Lambert Laboratories, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. E.","family":"Kocal","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, University of Guelph, Guelph; and Warner Lambert Laboratories, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Z. W.","family":"Wojcinski","sequence":"additional","affiliation":[{"name":"Department of Pathology, Ontario Veterinary College, University of Guelph, Guelph; and Warner Lambert Laboratories, Mississauga, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1988,5]]},"reference":[{"key":"e_1_2_2_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)39281-5"},{"key":"e_1_2_2_3_2","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.7003006"},{"key":"e_1_2_2_4_2","first-page":"37","article-title":"Mouse hepatitis virus immunofluorescence in formalin- or Bouin's-fixed tissues using trypsin digestion","volume":"32","author":"Brownstein DG","year":"1982","unstructured":"Brownstein DG, Barthold SW: Mouse hepatitis virus immunofluorescence in formalin- or Bouin's-fixed tissues using trypsin digestion. Lab Anim Sci 32: 37\u201339, 1982","journal-title":"Lab Anim Sci"},{"key":"e_1_2_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)83739-0"},{"key":"e_1_2_2_6_2","first-page":"1","volume-title":"Complications of Viral and Mycoplasmal Infections to Rodents in Toxicology Research Testing","author":"Collins MJ","year":"1986","unstructured":"Collins MJ: Prevalence of pathogenic murine viruses and mycoplasmas that are currently a problem in research. In: Complications of Viral and Mycoplasmal Infections to Rodents in Toxicology Research Testing, ed. Hamm TEJr. pp. 1\u20136. Hemisphere Publishing Co. New York, NY, 1986"},{"key":"e_1_2_2_7_2","first-page":"588","article-title":"Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues","volume":"55","author":"Damjanov I","year":"1986","unstructured":"Damjanov I, Mildner B, Knowles BB: Immunohistochemical localization of the epidermal growth factor receptor in normal human tissues. Lab Invest 55: 588\u2013592, 1986","journal-title":"Lab Invest"},{"key":"e_1_2_2_8_2","first-page":"655","article-title":"A subclinical epizootic of sialodacryoadenitis in rats","volume":"32","author":"Eiscnbrandt DL","year":"1982","unstructured":"Eiscnbrandt DL, Hubbard GB, Schmidt RE: A subclinical epizootic of sialodacryoadenitis in rats. Lab Anim Sci 32: 655\u2013659, 1982","journal-title":"Lab Anim Sci"},{"key":"e_1_2_2_9_2","first-page":"589","article-title":"Effects of sialodacryoadenitis virus and rat corona virus on maternal reproductive parameters and neonatal viability","volume":"36","author":"Feuston MH","year":"1986","unstructured":"Feuston MH, Kerstetter SL, Singer EJ: Effects of sialodacryoadenitis virus and rat corona virus on maternal reproductive parameters and neonatal viability. Lab Anim Sci 36: 589\u2013590, 1986","journal-title":"Lab Anim Sci"},{"key":"e_1_2_2_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(79)90124-7"},{"key":"e_1_2_2_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001560108"},{"key":"e_1_2_2_12_2","first-page":"201","article-title":"The post-natal development of the rat submaxillary gland","volume":"93","author":"Jacoby F","year":"1959","unstructured":"Jacoby F, Leeson CR: The post-natal development of the rat submaxillary gland. J Anat 93: 201\u2013220, 1959","journal-title":"J Anat"},{"key":"e_1_2_2_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587501200305"},{"key":"e_1_2_2_14_2","first-page":"613","article-title":"Sialodacryoadenitis in the rat. A light and electron microscopic study","volume":"88","author":"Jonas AM","year":"1969","unstructured":"Jonas AM, Craft J, Black L, Bhatt PN: Sialodacryoadenitis in the rat. A light and electron microscopic study. Arch Pathol 88: 613\u2013622, 1969","journal-title":"Arch Pathol"},{"key":"e_1_2_2_15_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1060197"},{"key":"e_1_2_2_16_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.17.5940"},{"key":"e_1_2_2_17_2","first-page":"287","article-title":"An electron microscopic study of the rat submaxillary gland during its post-natal development and in the adult","volume":"93","author":"Leeson CR","year":"1959","unstructured":"Leeson CR, Jacoby F: An electron microscopic study of the rat submaxillary gland during its post-natal development and in the adult. J Anat 93: 287\u2013295, 1959","journal-title":"J Anat"},{"key":"e_1_2_2_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/28.8.6969274"},{"key":"e_1_2_2_19_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.19.6059"},{"key":"e_1_2_2_20_2","first-page":"255","article-title":"Comparison of strain susceptibility to experimental sialodacryoadenitis in rats","volume":"34","author":"Percy DH","year":"1984","unstructured":"Percy DH, Hanna PE, Paturzo F, Bhatt PN: Comparison of strain susceptibility to experimental sialodacryoadenitis in rats. Lab Anim Sci 34: 255\u2013260, 1984","journal-title":"Lab Anim Sci"},{"key":"e_1_2_2_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00982668"},{"key":"e_1_2_2_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.1986.tb00566.x"},{"key":"e_1_2_2_23_2","first-page":"497","article-title":"Isolation of rat epidermal growth factor (r-EGF): chemical, biological and immunological comparisons with mouse and human EGF","volume":"84","author":"Schaudies RP","year":"1986","unstructured":"Schaudies RP, Savage CRJr: Isolation of rat epidermal growth factor (r-EGF): chemical, biological and immunological comparisons with mouse and human EGF. Comp Biochem Physiol 84B: 497\u2013505, 1986","journal-title":"Comp Biochem Physiol"},{"key":"e_1_2_2_24_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3492044"},{"key":"e_1_2_2_25_2","first-page":"157","article-title":"An immunofluorescent test for detection of serum antibody to rodent coronaviruses","volume":"33","author":"Smith AL","year":"1983","unstructured":"Smith AL: An immunofluorescent test for detection of serum antibody to rodent coronaviruses. Lab Anim Sci 33: 157\u2013160, 1983","journal-title":"Lab Anim Sci"},{"key":"e_1_2_2_26_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6572416"},{"key":"e_1_2_2_27_2","first-page":"1030","article-title":"Role of epidermal growth factor in carcinogenesis","volume":"46","author":"Stoscheck CM","year":"1986","unstructured":"Stoscheck CM, King LEJr: Role of epidermal growth factor in carcinogenesis. Cancer Res 46: 1030\u20131037, 1986","journal-title":"Cancer Res"},{"key":"e_1_2_2_28_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3090686"},{"key":"e_1_2_2_29_2","first-page":"4651","article-title":"Importance of epidermal growth factor in implantation and growth of mouse mammary tumor in female nude mice","volume":"47","author":"Tsutsumi O","year":"1987","unstructured":"Tsutsumi O, Tsutsumi A, Oka T: Importance of epidermal growth factor in implantation and growth of mouse mammary tumor in female nude mice. Cancer Res 47: 4651\u20134653, 1987","journal-title":"Cancer Res"},{"key":"e_1_2_2_30_2","doi-asserted-by":"publisher","DOI":"10.1258\/002367780781071229"},{"key":"e_1_2_2_31_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300308"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588802500301","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588802500301","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:27:49Z","timestamp":1777663669000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588802500301"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,5]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1988,5]]}},"alternative-id":["10.1177\/030098588802500301"],"URL":"https:\/\/doi.org\/10.1177\/030098588802500301","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,5]]}}}