{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:46:08Z","timestamp":1777920368417,"version":"3.51.4"},"reference-count":52,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1988,11,1]],"date-time":"1988-11-01T00:00:00Z","timestamp":594345600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1988,11]]},"abstract":"<jats:p>Tissues were examined from 26 male Holstein veal calves given large amounts of dietary zinc. All calves had been fed 706 \u03bcg zinc\/g of milk replacer for 28 days before the first death occurred. Calves died naturally (14, group A) or were euthanatized (12, group B) after 23 days of feeding a lower concentration of zinc (150 \u03bcg\/g). Average amounts of zinc in liver (wet weight) were 345.72 \u03bcg\/g (group A) and 344.84 \u03bcg\/g (group B). Mean kidney zinc concentrations were 219.0 \u03bcg\/g (group A) and 252.38 \u03bcg\/g (group B). Tissue manganese, copper, and iron levels were normal. Changes at necropsy included pneumonia, fluid digesta, and petechiae and infarcts in liver, kidney, and heart (as a result of bacterial infections). Histological changes that were directly attributed to dietary zinc intake were: marked atrophy and necrosis of pancreatic acinar tissue (group A); multifocal fibrosis of pancreatic acini (group B); multifocal renal cortical fibrosis with necrosis in convoluted tubules and loops of Henle, and with intratubular mineralization (groups A and B). Hepatic midzonal mineralization and fibrosis of the adrenal zona glomerulosa were seen in group B calves.<\/jats:p>","DOI":"10.1177\/030098588802500612","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T12:39:02Z","timestamp":1264509542000},"page":"484-491","source":"Crossref","is-referenced-by-count":20,"title":["A Pathologic and Toxicologic Evaluation of Veal Calves Fed Large Amounts of Zinc"],"prefix":"10.1177","volume":"25","author":[{"given":"T. W.","family":"Graham","sequence":"first","affiliation":[{"name":"Departments of Pathology and Medicine, Veterinary Medicine Teaching and Research Center, School of Veterinary Medicine, University of California-Davis, Tulare, CA; and Department of Nutrition, University of California, Davis, CA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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