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Lesions were characterized by surface denudation and diffuse intimal thickening due to myointimal hyperplasia and deposition of extracellular matrix. Affected intima was lined by hyperplastic, poorly differentiated endothelial cells and contained round to oval cells with characteristics of smooth muscle cells. After 9 weeks, thickened intima was vascularized and composed of spindle-shaped cells and fibrillar stroma. Intimal sclerosis and localized proliferative papillary projections in the vena cava cranial to areas of myointimal hyperplasia occurred infrequently. Traumatic lesions, regardless of location or severity, did not extend below the internal elastic membrane. Inflammatory cellular responses, when present, were minimal. The location, distribution, and morphogenesis of catheter-related cardiovascular lesions distinguishes them from those induced by chemical toxicity or pharmacotoxicity.<\/jats:p>","DOI":"10.1177\/030098588802500613","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T12:39:02Z","timestamp":1264509542000},"page":"492-502","source":"Crossref","is-referenced-by-count":15,"title":["Cardiovascular Complications of Chronic Catheterization of the Jugular Vein in the Dog"],"prefix":"10.1177","volume":"25","author":[{"given":"G. M.","family":"Mesfin","sequence":"first","affiliation":[{"name":"Pathology and Toxicology Research, The Upjohn Company, Kalamazoo, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Higgins","sequence":"additional","affiliation":[{"name":"Pathology and Toxicology Research, The Upjohn Company, Kalamazoo, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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