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Predilection sites for viral persistence were cerebral cortex and hippocampus; in other areas of brain and spinal cord, viral antigens were in single neurons or small groups of neurons. There was no morphological evidence of cellular alteration due to viral persistence. Perivascular lymphocytic infiltrations were in affected nervous tissue. It is concluded that the central nervous system is an important location for persistence of BVDV.<\/jats:p>","DOI":"10.1177\/030098588902600105","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T12:13:02Z","timestamp":1264507982000},"page":"26-32","source":"Crossref","is-referenced-by-count":46,"title":["Viral Antigen Distribution in the Central Nervous System of Cattle Persistently Infected with Bovine Viral Diarrhea Virus"],"prefix":"10.1177","volume":"26","author":[{"given":"A.","family":"Fernandez","sequence":"first","affiliation":[{"name":"Department of Pathology and Department of Virology, School of Veterinary Medicine, Hannover, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hewicker","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Virology, School of Veterinary Medicine, Hannover, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Trautwein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Virology, School of Veterinary Medicine, Hannover, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Pohlenz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Virology, School of Veterinary Medicine, Hannover, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Liess","sequence":"additional","affiliation":[{"name":"Department of Pathology and Department of Virology, School of Veterinary Medicine, Hannover, Federal Republic of Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"bibr1-030098588902600105","first-page":"242","volume":"14","author":"Baer S","year":"1985","journal-title":"Zentralbl Veterinarmed [C]"},{"key":"bibr2-030098588902600105","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2460\/javma.1987.190.11.1449","volume":"190","author":"Baker J","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"bibr3-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1136\/vr.118.12.321"},{"key":"bibr4-030098588902600105","first-page":"363","volume":"46","author":"Bielefeldt Ohmann H","year":"1982","journal-title":"Can J Comp Med"},{"key":"bibr5-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5288(18)32272-0"},{"key":"bibr6-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1177\/35.6.3033062"},{"key":"bibr7-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-68-7-1971"},{"key":"bibr8-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1080\/01652176.1983.9693889"},{"key":"bibr9-030098588902600105","doi-asserted-by":"crossref","first-page":"573","DOI":"10.2460\/ajvr.1985.46.03.573","volume":"46","author":"Bolin SR","year":"1985","journal-title":"Am J Vet Res"},{"key":"bibr10-030098588902600105","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2460\/javma.1987.190.08.1015","volume":"190","author":"Bolin SR","year":"1987","journal-title":"J Am Vet Med Assoc"},{"key":"bibr11-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1136\/vr.114.22.535"},{"key":"bibr12-030098588902600105","first-page":"449","volume":"172","author":"Coria MF","year":"1978","journal-title":"Am Vet Med Assoc"},{"key":"bibr13-030098588902600105","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.2460\/ajvr.1980.41.12.1938","volume":"41","author":"Cutlip RC","year":"1980","journal-title":"Am J Vet Res"},{"key":"bibr14-030098588902600105","first-page":"61","volume":"16","author":"Frey HR","year":"1971","journal-title":"Zentralbl Veterinarmed [B]"},{"key":"bibr15-030098588902600105","first-page":"245","volume":"16","author":"Hummel G","year":"1975","journal-title":"Z Hirn-forschg"},{"key":"bibr16-030098588902600105","first-page":"576","volume":"94","author":"Hyera JMK","year":"1987","journal-title":"Dtsch Tier\u00e4rztl Wschr"},{"key":"bibr17-030098588902600105","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/103.3.447"},{"key":"bibr18-030098588902600105","volume-title":"Viral Infections of the Nervous System","author":"Johnson RT","year":"1984"},{"key":"bibr19-030098588902600105","unstructured":"19 Kaufmann J: Untersuchungen \u00fcber die Fr\u00fchentwicklung des Kleinhirns beim Rind. 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