{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T06:35:08Z","timestamp":1784010908327,"version":"3.55.0"},"reference-count":36,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1989,1,1]],"date-time":"1989-01-01T00:00:00Z","timestamp":599616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>Sixteen choroid plexus (CP) tumors in 12 male and four female adult dogs were analyzed microscopically. Tumors were in the lateral (six), third (six), and fourth (four) ventricles. The average age of the dogs was 6 years. Tumors were classified by the following criteria: 1) choroid plexus papilloma (CPP), which resembled normal choroid plexus and had low mitotic activity; 2) choroid plexus papilloma with atypical features (atypical CPP), which had increased cellular density, nuclear atypia, two to four mitoses per 40 \u00d7 microscopic field, necrosis, and infiltration of the brain parenchyma and\/or leptomeninges; and 3) choroid plexus carcinoma (CPC), which had marked nuclear atypia, poorly formed papillae, &gt;four mitoses per 40 \u00d7 microscopic field, abnormal mitotic figures, and\/or extraneural metastasis. The 16 tumors were classified either as CPP or atypical CPP (none as CPC). Statistically significant associations between brain infiltration and necrosis and atypical CPP were identified. Immunohistochemical studies in 11 tumors demonstrated staining for keratin in three tumors, two of which also reacted with carcinoembryonic antigen (CEA). There was no immunoreactivity with glial fibrillary acidic protein or epithelial membrane antigen. Choroid plexus from one of three control dogs stained focally for cytokeratin only. It is concluded that normal choroid plexus and CP tumors in the dog express epithelial, but not glial differentiation.<\/jats:p>","DOI":"10.1177\/030098588902600109","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T12:13:02Z","timestamp":1264507982000},"page":"55-64","source":"Crossref","is-referenced-by-count":45,"title":["A Histologic and Immunocytochemical Study of Choroid Plexus Tumors of the Dog"],"prefix":"10.1177","volume":"26","author":[{"given":"J. L.","family":"Ribas","sequence":"first","affiliation":[{"name":"Departments of Neuropathology and Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, DC; and Scott-Ritchey Research Program, School of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mena","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology and Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, DC; and Scott-Ritchey Research Program, School of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. G.","family":"Braund","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology and Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, DC; and Scott-Ritchey Research Program, School of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. A.","family":"Sesterhenn","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology and Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, DC; and Scott-Ritchey Research Program, School of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Toivio-Kinnucan","sequence":"additional","affiliation":[{"name":"Departments of Neuropathology and Genitourinary Pathology, Armed Forces Institute of Pathology, Washington, DC; and Scott-Ritchey Research Program, School of Veterinary Medicine, Auburn University, Auburn, AL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1989,1,1]]},"reference":[{"key":"bibr1-030098588902600109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1983.tb02308.x"},{"key":"bibr2-030098588902600109","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400605"},{"key":"bibr3-030098588902600109","doi-asserted-by":"publisher","DOI":"10.1007\/BF00691101"},{"key":"bibr4-030098588902600109","unstructured":"4 Burger PC, Vogel FS: Surgical Pathology of the Nervous System and its Coverings, 2nd ed., pp. 320\u2013326. 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