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Morphologic evidence of neuronal storage and massive accumulation of GM\n                    <jats:sub>2<\/jats:sub>\n                    ganglioside were present. \u03b2-hexosaminidase activity in plasma, liver, kidney, and brain, assayed with use of unsulfated fluorogenic substrates, was normal. There was no pathologic accumulation or aberrant localization of phosphorylated neurofilaments in neurons. Activity of cortical neurotransmitter synthesizing enzymes, choline acetyltransferase, and glutamate decarboxylase was unaffected. Ligand binding to carrier sites for choline high affinity uptake identified with [\n                    <jats:sup>3<\/jats:sup>\n                    H]hemicholinium-3 was increased, whereas post-synaptic binding to muscarinic cholinergic ([\n                    <jats:sup>3<\/jats:sup>\n                    H]QNB) and gamma-aminobutryic acid receptors ([\n                    <jats:sup>3<\/jats:sup>\n                    H]muscimol) was reduced.\n                  <\/jats:p>","DOI":"10.1177\/030098588902600203","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T11:43:05Z","timestamp":1264506185000},"page":"114-120","source":"Crossref","is-referenced-by-count":29,"title":["Canine GM\n                    <sub>2<\/sub>\n                    Gangliosidosis: Morphological and Biochemical Analysis"],"prefix":"10.1177","volume":"26","author":[{"given":"H. 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