{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:46:42Z","timestamp":1777920402905,"version":"3.51.4"},"reference-count":16,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>\n                    To document the diagnostic features of foreign-body pneumonias, four commonly used orally administered medicaments were instilled into the lungs of Sprague-Dawley rats. Rats in each group received a single 0.4 ml dose of either barium sulfate suspension (BaSO\n                    <jats:sub>4<\/jats:sub>\n                    ), mineral oil, Pepto-bismol\u00ae, or Kaopectate\u00ae inoculated into a lung via a mainstem bronchus. The other lung served as a non-inoculated control. Rats were euthanatized on post-inoculation day 2 or 7 in order to document fully-developed, acute pulmonary lesions and developing, chronic pulmonary lesions, respectively. Light microscopic features of BaSO\n                    <jats:sub>4<\/jats:sub>\n                    -inoculated lungs were distinctive from changes in mineral oil-inoculated lungs at both post-inoculation days. On post-inoculation day 2, rats inoculated with BaSO\n                    <jats:sub>4<\/jats:sub>\n                    had pneumonia characterized by large numbers of alveolar macrophages containing green-to-brown granular material. There was minimal interstitial involvement. On post-inoculation day 2, mineral oil caused pneumonia characterized by giant cells and alveolar macrophages that had cytoplasms distended with variably-sized clear vacuoles. Lungs inoculated with BaSO\n                    <jats:sub>4<\/jats:sub>\n                    or mineral oil had changed little on post-inoculation day 7 compared to the light microscopic features observed on day 2. On post-inoculation day 2, rats inoculated with either Pepto-bismol\u00ae or Kaopectate\u00ae had broncho-interstitial pneumonia with areas of necrosis and hemorrhage. On post-inoculation day 7, lungs inoculated with Pepto-bismol\u00ae or Kaopectate\u00ae had extensive fibrosis within alveolar lumens. Energy dispersive spectroscopy performed on sections of lung from rats given BaSO\n                    <jats:sub>4<\/jats:sub>\n                    , Pepto-bismol\u00ae, and Kaopectate\u00ae yielded a unique elemental spectrum for each compound in situ on post-inoculation days 2 and 7. We conclude that pulmonary responses differ among these compounds and that energy dispersive spectroscopy is a useful diagnostic adjunct for the definitive identification of elements comprising BaSO\n                    <jats:sub>4<\/jats:sub>\n                    , Pepto-bismol\u00ae, and Kaopectate\u00ae in situ in affected lungs.\n                  <\/jats:p>","DOI":"10.1177\/030098588902600604","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T08:07:44Z","timestamp":1264493264000},"page":"479-487","source":"Crossref","is-referenced-by-count":5,"title":["Histopathologic Findings and Energy Dispersive X-ray Spectroscopic Analysis of Experimentally Induced Foreign-body Pneumonias in Rats"],"prefix":"10.1177","volume":"26","author":[{"given":"R. F.","family":"Slocombe","sequence":"first","affiliation":[{"name":"Departments of Pathology and Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. G.","family":"Evans","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. J.","family":"Derksen","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,11,1]]},"reference":[{"key":"bibr1-030098588902600604","first-page":"96","volume-title":"The Lung: Structure, Function, and Disease","author":"Abraham JL.","year":"1978"},{"key":"bibr2-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1177\/030098588702400608"},{"key":"bibr3-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1177\/030098588502200305"},{"key":"bibr4-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500310"},{"key":"bibr5-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1975.10666701"},{"key":"bibr6-030098588902600604","first-page":"95","volume":"34","author":"Funahashi A","year":"1977","journal-title":"Br J Ind Med"},{"key":"bibr7-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1258\/002367781780959107"},{"key":"bibr8-030098588902600604","first-page":"199","volume":"119","author":"Hargest TE","year":"1985","journal-title":"Am J Pathol"},{"key":"bibr9-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(82)80291-8"},{"key":"bibr10-030098588902600604","first-page":"430","volume":"54","author":"Huston J","year":"1952","journal-title":"Arch Pathol"},{"key":"bibr11-030098588902600604","first-page":"321","volume":"7","author":"Johnson FB.","year":"1972","journal-title":"Pathol Annu"},{"key":"bibr12-030098588902600604","first-page":"279","volume":"57","author":"Kay S","year":"1954","journal-title":"Arch Pathol"},{"key":"bibr13-030098588902600604","first-page":"69","volume-title":"Scanning Electron Microscopy. A Student's Handbook","author":"Postek MT","year":"1980"},{"key":"bibr14-030098588902600604","first-page":"96","volume-title":"Pathology of Laboratory Animals","volume":"1","author":"Stookey JL","year":"1979","edition":"1"},{"key":"bibr15-030098588902600604","first-page":"77","volume-title":"Pathology Annual","author":"Vallyathan NV","year":"1980"},{"key":"bibr16-030098588902600604","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841101)54:9<1814::AID-CNCR2820540909>3.0.CO;2-V"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588902600604","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098588902600604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:29:27Z","timestamp":1777663767000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098588902600604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1177\/030098588902600604"],"URL":"https:\/\/doi.org\/10.1177\/030098588902600604","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}