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A 2.5% solution of ferritin was injected into the ligated loops in mid-jejunum, in terminal ileum, in the ascending colon adjacent to the ileocecal junction, and in the proximal loop of the ascending colon containing gut-associated lymphoid tissue. After exposure times that ranged from 82 to 165 minutes, ferritin was detected in M cells of domes in the small intestine, as well as in cells in follicle-associated epithelium of proprial lymphoid nodules and lymphoglandular complexes of colon that morphologically resembled M cells of small intestine. Ferritin was found in apical invaginations, apical vesicles, multivesicular bodies, basal vesicles, and adjacent intercellular spaces. In addition to ferritin, apical vesicles, multivesicular bodies, and intercellular spaces contained 50-nm membrane-bound particles. More ferritin was endocytosed by M cells of the small intestine than by M cells of the large intestine. In the large intestine, higher amounts of ferritin were found in M cells of follicle-associated epithelium overlying proprial lymphoid nodules than in M cells of follicle-associated epithelium in the depth of lymphoglandular complexes. Based on these results, we concluded that M cells of follicle-associated epithelium in the colon of calves provide a route for antigen uptake into the intestinal lymphoid system.<\/jats:p>","DOI":"10.1177\/030098589202900204","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:19:33Z","timestamp":1268068773000},"page":"120-128","source":"Crossref","is-referenced-by-count":14,"title":["Uptake of Ferritin by Follicle-associated Epithelium in the Colon of Calves"],"prefix":"10.1177","volume":"29","author":[{"given":"M.","family":"Paar","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Pathologie, Tier\u00e4rztliche Hochschule Hannover, B\u00fcnteweg 17, 3000 Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. 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