{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:32Z","timestamp":1787018792878,"version":"build-2736575974"},"reference-count":17,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1992,5,1]],"date-time":"1992-05-01T00:00:00Z","timestamp":704678400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1992,5]]},"abstract":"<jats:p>Extracranial metastasis of primary central nervous system neoplasms is uncommon and has not been described in the dog. We report the clincopathologic features of intracranial meningioma with pulmonary metastasis in three dogs (case No. 1: 13-year-old castrated male Boxer dog; case No. 2: 14-year-old spayed female Dachshund; case No. 3: 6-year-old spayed female German Shepherd Dog). Case No. 1 presented with ataxia, lethargy, vomiting, and leaning and falling to the right, and had a transient remission following radiation and corticosteroid therapy; case No. 2 had a history of seizures that were unresponsive to primidone, left-sided postural reaction deficits, ataxia, and circling to the right; case No. 3 had only intermittent episodes of vomiting. Computed tomography of case Nos. 1 and 2 revealed peripherally located homogeneous contrast-enhancing intracranial masses. Postmortem examination revealed intracranial masses with single or multiple pulmonary nodules in all three cases. Histologically, the intracranial and pulmonary masses were meningotheliomatous meningiomas with atypical features including brain infiltration, necrosis, nuclear atypia, prominent nucleoli, and moderate cell density. All of the primary meningiomas had low mitotic rates. The current interest in early diagnosis and aggressive clinical\/surgical management of canine patients with meningioma and other primary central nervous system neoplasms will likely result in an increased detection of extracranial metastases.<\/jats:p>","DOI":"10.1177\/030098589202900302","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:19:33Z","timestamp":1268068773000},"page":"196-202","source":"Crossref","is-referenced-by-count":32,"title":["Intracranial Meningioma with Pulmonary Metastasis in Three Dogs"],"prefix":"10.1177","volume":"29","author":[{"given":"F. Y.","family":"Schulman","sequence":"first","affiliation":[{"name":"Department of Pathology, Angell Memorial Animal Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Ribas","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Armed Forces Institute of Pathology, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. L.","family":"Carpenter","sequence":"additional","affiliation":[{"name":"Department of Pathology, Angell Memorial Animal Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. F.","family":"Sisson","sequence":"additional","affiliation":[{"name":"Department of Pathology, Angell Memorial Animal Hospital, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. A.","family":"LeCouteur","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1992,5]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1973.163.02.151"},{"key":"e_1_2_2_3_1","first-page":"554","volume-title":"Diseases of the Cat","author":"Averill DR","year":"1987","unstructured":"Averill DRJr: Tumors of the nervous system. In: Diseases of the Cat, ed. Holzworth J, pp. 554\u2013565. WB Saunders, Philadelphia, PA, 1987."},{"key":"e_1_2_2_4_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1986.188.04.414"},{"key":"e_1_2_2_5_1","first-page":"241","article-title":"Central nervous system meningiomas","volume":"8","author":"Braund KG","year":"1986","unstructured":"Braund KG, Ribas JL: Central nervous system meningiomas. Compend Contin Educ Pract Vet 8: 241\u2013250, 1986.","journal-title":"Compend Contin Educ Pract Vet"},{"key":"e_1_2_2_6_1","first-page":"640","article-title":"Tumors of the nervous system and eye","author":"Cordy DR","year":"1990","unstructured":"Cordy DR: Tumors of the nervous system and eye. In: Tumors of Domestic Animals, ed. Moulton JE, 3rd ed., pp. 640\u2013665. 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Masson Publishing USA, Inc, New York, NY, 1982.","journal-title":"Meningiomas: Biology, Pathology, and Differential Diagnosis"},{"key":"e_1_2_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(79)80051-9"},{"key":"e_1_2_2_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000386079"},{"key":"e_1_2_2_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/030098588602300404"},{"key":"e_1_2_2_15_1","first-page":"473","author":"Russell DS","year":"1989","unstructured":"Russell DS, Rubinstein LJ: Pathology of Tumors of the Nervous System, revised by Rubinstein LJ, 5th ed., pp. 473\u2013479. Williams and Wilkins, Baltimore, MD, 1989.","journal-title":"Pathology of Tumors of the Nervous System"},{"key":"e_1_2_2_16_1","doi-asserted-by":"publisher","DOI":"10.2460\/javma.1986.188.08.851"},{"key":"e_1_2_2_17_1","first-page":"480","article-title":"Extracranial bone metastases from intracranial meningiomas","volume":"12","author":"Wasserkrug R","year":"1979","unstructured":"Wasserkrug R, Peyser E, Lichtig C: Extracranial bone metastases from intracranial meningiomas. Surg Neurol 12: 480\u2013484, 1979.","journal-title":"Surg Neurol"},{"key":"e_1_2_2_18_1","first-page":"101","author":"Willis RA","year":"1973","unstructured":"Willis RA: The Spread of Tumors in the Human Body, p. 101. Butterworth & Co, London, England, 1973.","journal-title":"The Spread of Tumors in the Human Body"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589202900302","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589202900302","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:31:33Z","timestamp":1777663893000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098589202900302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,5]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,5]]}},"alternative-id":["10.1177\/030098589202900302"],"URL":"https:\/\/doi.org\/10.1177\/030098589202900302","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,5]]}}}