{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T18:27:00Z","timestamp":1784831220674,"version":"3.55.0"},"reference-count":22,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>On routine blood screens, persistent conjugated hyperbilirubinemia was discovered in two groups of closely related adult female golden lion tamarins ( Leontopithecus rosalia rosalia, n = 8). Bromosulfophthalein (BSP) retention tests were performed on four hyperbilirubinemic and three control tamarins. BSP excretion was delayed in hyperbilirubinemic tamarins as compared with controls. Grossly, liver of affected tamarins was dark brown to black, with a prominent reticulated pattern. Histologic examination revealed abundant intrahepatic pigment, primarily in a centrilobular and midzonal distribution. Most of the pigment did not react with Perls' Prussian blue method for iron. Hall's method for bilirubin, or the Armed Forces Institute of Pathology acid-fast method for lipofuscin but was positive with Fontana and lipofuscin-ferric ferricyanide reduction techniques. Liver from control golden lion tamarins had intrahepatocellular Perls' iron-positive pigment diffusely throughout the lobule with a small amount of Fontana method-positive pigment. Ultrastructurally, hepatocytes from a hyperbilirubinemic tamarin contained pleomorphic electron-dense structures within lysosomes. Transport studies demonstrated secretion of fluorescein isothiocyanate-labeled glycocholic acid, a fluorescent bile acid analog, into bile canaliculi and no secretion of carboxydichlorofluorescein diacetate, a non-bile acid organic anion, by liver from a hyperbilirubinemic tamarin. In contrast, control liver secreted carboxydichlorofluorescein diacetate readily into bile canaliculi. The clinicopathologic presentation of this syndrome in golden lion tamarins is similar to that described for Dubin-Johnson syndrome of human beings.<\/jats:p>","DOI":"10.1177\/030098589303000601","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:19:33Z","timestamp":1268068773000},"page":"491-498","source":"Crossref","is-referenced-by-count":16,"title":["Dubin-Johnson-like Syndrome in Golden Lion Tamarins (\n                    <i>Leontopithecus rosalia rosalia<\/i>\n                    )"],"prefix":"10.1177","volume":"30","author":[{"given":"F. Y.","family":"Schulman","sequence":"first","affiliation":[{"name":"Department of Pathology, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"Montali","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Bush","sequence":"additional","affiliation":[{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. B.","family":"Citino","sequence":"additional","affiliation":[{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. A.","family":"Tell","sequence":"additional","affiliation":[{"name":"Department of Animal Health, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. D.","family":"Ballou","sequence":"additional","affiliation":[{"name":"Department of Research, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. L.","family":"Hutson","sequence":"additional","affiliation":[{"name":"Department of Research, National Zoological Park, Smithsonian Institution, Washington DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. St.","family":"Pierre","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tufts University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. F.","family":"Dufour","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tufts University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Gatmaitan","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tufts University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. B.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Armed Forces Institute of Pathology, Washington, DC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. M.","family":"Arias","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tufts University School of Medicine, Boston, MA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1993,11,1]]},"reference":[{"key":"bibr1-030098589303000601","volume-title":"International Golden Lion Tamarin Studbook","author":"Ballou J","year":"1990"},{"key":"bibr2-030098589303000601","first-page":"246","volume-title":"Hepatology: A Textbook of Liver Disease","author":"Blanckaert N","year":"1982"},{"key":"bibr3-030098589303000601","first-page":"419","volume-title":"The Liver Biology and Pathobiology","author":"Chowdhury JR","year":"1988","edition":"2"},{"key":"bibr4-030098589303000601","first-page":"2","volume":"2","author":"Cornelius CE","year":"1970","journal-title":"Comp Pathol Bull"},{"key":"bibr5-030098589303000601","first-page":"601","volume-title":"Bile Pigments and Jaundice: Molecular, Metabolic, and Medical Aspects","author":"Cornelius CE","year":"1986"},{"key":"bibr6-030098589303000601","first-page":"1315","volume-title":"The Liver: Biology and Path- obiology","author":"Cornelius CE","year":"1988","edition":"2"},{"key":"bibr7-030098589303000601","first-page":"709","volume":"146","author":"Cornelius CE","year":"1965","journal-title":"J Am Vet Med Assoc"},{"key":"bibr8-030098589303000601","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-195409000-00001"},{"key":"bibr9-030098589303000601","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(73)80097-6"},{"key":"bibr10-030098589303000601","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-407-01572-2.50008-3"},{"key":"bibr11-030098589303000601","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050408"},{"key":"bibr12-030098589303000601","unstructured":"Johnson FB: Genetic disorders of bilirubin metabolism.\n                      In\n                      : The Liver: International Academy of Pathology Monograph No. 13, pp. 12\u201320. 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