{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:48:39Z","timestamp":1777920519955,"version":"3.51.4"},"reference-count":14,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[1993,11,1]],"date-time":"1993-11-01T00:00:00Z","timestamp":752112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1993,11]]},"abstract":"<jats:p>Multicentric squamous cell carcinoma in situ was studied in 12 cats (eight castrated males and four spayed females). The neoplasms occurred in middle-aged to old (mean age = 12 years) mixed-breed cats with a variety of hair-coat colors. The lesions were found in haired pigmented regions of the skin, including the trunk, limbs, feet, head, and neck, and were unrelated to exposure to sunlight. Lesions occurred at multiple sites in nine cats and at solitary sites in three cats and were from 0.5 cm to 3.0 cm in diameter, irregular, slightly, elevated, plaque-like or papillated, and partially alopecic. Histologically, the lesions consisted of sharply demarcated regions of necoplastic, keratinocytic infiltration of the epidermal and follicular infundibular epithelium. Neoplastic cells were confined to the epithelium without frank invasion of the dermis. Two histologic subclasses of multicentric squamous cell carcinoma in situ were identified, the irregular nonhyperkeratotic type and the verrucous hyperkeratotic type. Three cats also had invasive squamous cell carcinoma adjacent to lesions characteristic of multicentric squamous cell carcinoma in situ. Grossly, these were solitary 2.0\u20134.0 cm-diameter firm, crusted, crateriform cutancous masses. During follow-up periods of 4 to 20 months (mean follow-up period = 11 months), neoplasms did not recur locally after surgical excision; however, similar lesions developed at new sites in four cats. None of the cats had evidence of metastases. Multicentric squamous cell carcinoma in situ in cats is a biologically premalignant neoplasm histologically similar to Bowen's disease in human beings.<\/jats:p>","DOI":"10.1177\/030098589303000607","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:19:33Z","timestamp":1268068773000},"page":"535-543","source":"Crossref","is-referenced-by-count":43,"title":["Multicentric Squamous Cell Carcinoma in situ Resembling Bowen's Disease in Cats"],"prefix":"10.1177","volume":"30","author":[{"given":"K. E.","family":"Baer","sequence":"first","affiliation":[{"name":"Department of Pathology, The Animal Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Helton","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The Animal Medical Center, New York, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1993,11,1]]},"reference":[{"key":"bibr1-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(87)70191-1"},{"key":"bibr2-030098589303000607","first-page":"241","volume":"30","author":"Bowen JT","year":"1912","journal-title":"J Cutan Dis"},{"key":"bibr3-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1979.tb01903.x"},{"key":"bibr4-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640280058019"},{"key":"bibr5-030098589303000607","unstructured":"Goldschmidt MH, Shofer FS: Skin Tumors of the Dog and Cat, p. 48. Pergamon, Tarrytown, NY, 1992."},{"key":"bibr6-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198612000-00010"},{"key":"bibr7-030098589303000607","first-page":"76","volume-title":"Veterinary Dermatopathology","author":"Gross TL","year":"1992"},{"key":"bibr8-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1986.01660220042010"},{"key":"bibr9-030098589303000607","unstructured":"Lever WF, Schaumburg-Lever G: Histopathology of the Skin, 7th ed., pp. 549\u2013551. JB Lippincott, Philadelphia, PA, 1990."},{"key":"bibr10-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1177\/030098589102800506"},{"key":"bibr11-030098589303000607","first-page":"440","volume":"29","author":"Rowland P","year":"1992","journal-title":"Vet Pathol"},{"key":"bibr12-030098589303000607","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1980.tb01223.x"},{"key":"bibr13-030098589303000607","first-page":"84","volume":"11","author":"Turrel JM","year":"1991","journal-title":"Proc Annu Conf Vet Cancer Soc"},{"key":"bibr14-030098589303000607","first-page":"330","volume-title":"Veterinary Dermatopathology","author":"Walder EJ","year":"1992"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589303000607","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589303000607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:32:51Z","timestamp":1777663971000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098589303000607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,11]]},"references-count":14,"journal-issue":{"issue":"6","published-print":{"date-parts":[[1993,11]]}},"alternative-id":["10.1177\/030098589303000607"],"URL":"https:\/\/doi.org\/10.1177\/030098589303000607","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,11]]}}}