{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T18:48:44Z","timestamp":1777920524180,"version":"3.51.4"},"reference-count":26,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>A comparative histopathologic study of 50 cases of pemphigus foliaceus and 47 cases of superficial folliculitis in the dog was undertaken to identify those histopathologic features important in differentiating these diseases. All cases were diagnosed by the Surgical Pathology Service of the Laboratory of Pathology of the University of Pennsylvania, School of Veterinary Medicine, between January 1986 and March 1991. These cases were followed clinically to determine the accuracy of the initial histopathologic diagnosis. Data were analyzed by Fisher's exact test for discrete data and the Mann-Whitney U-test for continuous data. A probability of &lt;0.05 was considered statistically significant. The following breeds were affected with pemphigus foliaceus: Akita, Brittany Spaniel, Chow Chow, Collie, Dachshund, Doberman Pinscher, English Cocker Spaniel, English Setter, Golden Retriever, Siberian Husky, Laborador Retriever, Miniature Schnauzer, Old English Sheepdog, Scottish Terrier, Chinese Shar Pei, Spitz, Shetland Sheep Dog, Weimeraner, and West Highland White Terrier. An increased risk of developing pemphigus foliaceus was noted in the Akita (OR = 37.8), English Springer Spaniel (OR = 20.7), Chow Chow (OR = 12.3), Chinese Shar Pei (OR = 7.9), and Collie (OR = 3.9). Pemphigus foliaceus had a higher average density of acantholytic cells (226 \u00b1 22.9) than superficial folliculitis (11.8 \u00b1 4.6), and acantholytic cells were 183 times more likely to be present in pemphigus foliaceus. The presence of rafts of acantholytic cells occurred in pemphigus foliaceus (23\/50) more often than superficial folliculitis (1\/47). Recornitication and reformation of pustules were, respectively, 13.4 and 3.6 times more likely to occur in pemphigus foliaceus. Finally, a longer pustule that bridges multiple hair follicles (2.3 \u00b1 0.20 mm and 1.31 \u00b1 0.10 mm, respectively) was seen in pemphigus foliaceus.<\/jats:p>","DOI":"10.1177\/030098589403100103","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T06:07:38Z","timestamp":1264486058000},"page":"19-27","source":"Crossref","is-referenced-by-count":28,"title":["Comparative Histopathology of Pemphigus Foliaceus and Superficial Folliculitis in the Dog"],"prefix":"10.1177","volume":"31","author":[{"given":"K. A.","family":"Kuhl","sequence":"first","affiliation":[{"name":"Section of Dermatology, Department of Clinical Studies, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F. S.","family":"Shofer","sequence":"additional","affiliation":[{"name":"Emergency Services, Department of Medicine, University of Pennsylvania School of Medicine, Hospital of the University of Pennsylvania, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. H.","family":"Goldschmidt","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Department of Pathobiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1994,1,1]]},"reference":[{"key":"bibr1-030098589403100103","first-page":"89","volume":"7","author":"Ackerman LJ","year":"1985","journal-title":"Compend Contin Educ Pract Vet"},{"key":"bibr2-030098589403100103","volume-title":"Statistical Methods in Cancer Research, Volume 1, The Analysis of Case-control Studies","author":"Breslow NE","year":"1980"},{"key":"bibr3-030098589403100103","first-page":"330","volume-title":"BMDP Statistical Software","author":"Engelman L","year":"1985"},{"key":"bibr4-030098589403100103","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80917-9"},{"key":"bibr5-030098589403100103","first-page":"911","volume":"2","author":"Halliwell REW","year":"1980","journal-title":"Compend Coltin Educ Pract Vet"},{"key":"bibr6-030098589403100103","first-page":"431","volume":"13","author":"Halliwell REW","year":"1977","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr7-030098589403100103","doi-asserted-by":"publisher","DOI":"10.1084\/jem.157.1.259"},{"key":"bibr8-030098589403100103","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12277087"},{"key":"bibr9-030098589403100103","first-page":"59","volume":"186","author":"Ihrke PJ","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"bibr10-030098589403100103","first-page":"67","volume":"186","author":"Ihrke PJ","year":"1985","journal-title":"J Am Vet Med Assoc"},{"key":"bibr11-030098589403100103","first-page":"1","volume":"53","author":"Koch PJ","year":"1990","journal-title":"Eur J Cell Biol"},{"key":"bibr12-030098589403100103","unstructured":"Lever WF: Histopathology of the Skin, 6th ed., pp. 110\u2013112. JB Lippincott Co, Philadelphia, PA, 1983."},{"key":"bibr13-030098589403100103","first-page":"189","volume":"16","author":"Manning TO","year":"1980","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr14-030098589403100103","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12460937"},{"key":"bibr15-030098589403100103","unstructured":"Muller GH, Kirk RW, Scott DW: Small Animal Dermatology, 4th ed. pp. 86\u201387, 250\u2013257, 498\u2013513. WB Saunders Co., Philadelphia, PA, 1989."},{"key":"bibr16-030098589403100103","first-page":"570","volume":"94","author":"Razsi L","year":"1990","journal-title":"J Invest Dermatol"},{"key":"bibr17-030098589403100103","unstructured":"Rubin E, Farber JL: Pathology, pp. 1238\u20131214. 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