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Other abnormalities in the colt's erythrocytes as compared with those of healthy horses ( n = 22\u201335) included increased activities of hexokinase and pyruvate kinase, decreased concentrations of reduced glutathione and reduced nicotinamide adenine dinucleotide phosphate (NADP), and increased concentration of oxidized NADP. Morphologic abnormalities included eccentrocytosis, pyknocytosis, anisocytosis, macrocytosis, and increased number of Howell-Jolly bodies. Scanning and transmission electron microscopic examinations revealed that eccentrocytes had contracted to spherical regions and thin collapsed regions. Eccentrocytes were more electron dense than were normal erythrocytes when examined by transmission electron microscopy. When exposed to acetylphenylhydrazine, erythrocytes from the G6PD-deficient colt produced more and smaller Heinz bodies than did erythrocytes from normal horses. Abnormalities in the colt's dam included presence of eccentrocytes and pyknocytes; her average erythrocyte G6PD activity was slightly below the range of reference values.<\/jats:p>","DOI":"10.1177\/030098589403100503","type":"journal-article","created":{"date-parts":[[2010,1,26]],"date-time":"2010-01-26T04:42:44Z","timestamp":1264480964000},"page":"518-527","source":"Crossref","is-referenced-by-count":30,"title":["Equine Glucose-6-phosphate Dehydrogenase Deficiency"],"prefix":"10.1177","volume":"31","author":[{"given":"S. L.","family":"Stockham","sequence":"first","affiliation":[{"name":"Department of Veterinary Pathology, University of Missouri-Columbia, Columbia, MO"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. W.","family":"Harvey","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences, University of Florida, Gainesville, FL"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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