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An autofluorescent pigment, identified as ceroid-lipofuscin by electron microscopy and staining properties, was found within neurons of the central and peripheral nervous systems. A diffuse reactive astrocytosis accompanied by multifocal microgliosis was visible in all areas of the brain. Retinal atrophy with intraneuronal lipopigment accumulation was also identified. Contrary to the human neuronal ceroid-lipofuscinoses, pigment deposition appeared to be restricted to neural tissues.<\/jats:p>","DOI":"10.1177\/030098589503200505","type":"journal-article","created":{"date-parts":[[2010,1,27]],"date-time":"2010-01-27T04:17:50Z","timestamp":1264565870000},"page":"485-488","source":"Crossref","is-referenced-by-count":23,"title":["Neuronal Ceroid-lipofuscinosis in a Cat"],"prefix":"10.1177","volume":"32","author":[{"given":"R.","family":"Bildfell","sequence":"first","affiliation":[{"name":"Departments of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, PEI, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Matwichuk","sequence":"additional","affiliation":[{"name":"Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, PEI, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Companion Animals, Atlantic Veterinary College, University of Prince Edward Island, PEI, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Ward","sequence":"additional","affiliation":[{"name":"Departments of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, PEI, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1995,9,1]]},"reference":[{"key":"bibr1-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320310610"},{"key":"bibr2-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1177\/030098589403100106"},{"key":"bibr3-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1989.tb01521.x"},{"key":"bibr4-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500213"},{"key":"bibr5-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(12)80231-2"},{"key":"bibr6-030098589503200505","first-page":"207","volume":"38","author":"Green PD","year":"1974","journal-title":"Can J Comp Med"},{"key":"bibr7-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420436"},{"key":"bibr8-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1994.tb03290.x"},{"key":"bibr9-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-057133-1.50011-4"},{"key":"bibr10-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1292\/jvms.55.829"},{"key":"bibr11-030098589503200505","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320420437"},{"key":"bibr12-030098589503200505","first-page":"133","volume":"16","author":"Sato T","year":"1967","journal-title":"J Electron Microsc"},{"key":"bibr13-030098589503200505","first-page":"497","volume-title":"Consultations in Feline Internal Medicine","author":"Wood PA","year":"1991"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589503200505","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589503200505","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:35:15Z","timestamp":1777664115000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098589503200505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,9]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,9]]}},"alternative-id":["10.1177\/030098589503200505"],"URL":"https:\/\/doi.org\/10.1177\/030098589503200505","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,9]]}}}