{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:33Z","timestamp":1787018793076,"version":"build-2736575974"},"reference-count":54,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[1996,3,1]],"date-time":"1996-03-01T00:00:00Z","timestamp":825638400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Vet Pathol"],"published-print":{"date-parts":[[1996,3]]},"abstract":"<jats:p>Cytospin preparations of fine-needle aspirates from 21 dogs with peripheral lymphadenopathy (18 with lymphoma and three with lymph node hyperplasia) were studied by combining morphologic and immunocytochemical analysis. Fine-needle aspirates were taken from at least two enlarged lymph nodes, and the diagnosis was based on air-dried smears stained with May-Gr\u00fcnwald Giemsa. Fine-needle aspiration biopsy always provided an adequate quality and quantity of cells to perform morphologic and immunologic studies. Immunophenotyping was performed on cytospin preparations with a panel of eight monoclonal antibodies specific for canine cell surface antigens and one rabbit polyclonal antibody (A452) against human CD3, which cross-reacts with dog antigen. The immunocytochemical study resulted in the diagnosis of 14 B-cell lymphomas (CD21 +, CD3-) and three T-cell lymphomas (all CD3 +, two CD8+). One lymphoma lacked surface antigens specific for the B- or T-cell lineage and was classified as non-B-non-T lymphoma (CD21-, CD3-, CD4-, CD8-). The monoclonal antibodies CA12.10C12, CA4.1D3, and CA1D6 and the polyclonal antibody A452, used as a group, appeared to be the most useful reagents to suggest lymphoid origin and to discriminate between T- and B-cell phenotype. Cytospin preparations in combination with immunocytochemistry provided a practical, economical, and accurate method for the diagnosis and phenotyping of canine lymphoma.<\/jats:p>","DOI":"10.1177\/030098589603300210","type":"journal-article","created":{"date-parts":[[2010,3,8]],"date-time":"2010-03-08T17:18:27Z","timestamp":1268068707000},"page":"204-212","source":"Crossref","is-referenced-by-count":63,"title":["Canine Lymphoma: Immunocytochemical Analysis of Fine-needle Aspiration Biopsy"],"prefix":"10.1177","volume":"33","author":[{"given":"M.","family":"Caniatti","sequence":"first","affiliation":[{"name":"Istituto di Anatomia Patologica Veterinaria e Patologia Aviare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Roccabianca","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Patologica Veterinaria e Patologia Aviare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Scanziani","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Patologica Veterinaria e Patologia Aviare"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Paltrinieri","sequence":"additional","affiliation":[{"name":"Istituto di Patologia Generale Veterinaria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. F.","family":"Moore","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Milano, Milano, Italy; and Department of Pathology, School of Veterinary Medicine, University of California, Davis, CA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1996,3,1]]},"reference":[{"key":"bibr1-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(88)90044-X"},{"key":"bibr2-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1177\/030098588802500502"},{"key":"bibr3-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020205"},{"key":"bibr4-030098589603300210","first-page":"821","volume":"8","author":"Atkinson K","year":"1980","journal-title":"Exp Hematol"},{"key":"bibr5-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080506"},{"key":"bibr6-030098589603300210","first-page":"167","volume":"3","author":"Carter RF","year":"1988","journal-title":"Semin Vet Med Surg Small Animal"},{"key":"bibr7-030098589603300210","first-page":"154","volume":"50","author":"Carter RF","year":"1986","journal-title":"Can J Vet Res"},{"key":"bibr8-030098589603300210","first-page":"159","volume":"19","author":"Cotter SM","year":"1983","journal-title":"J Am Anim Hosp Assoc"},{"key":"bibr9-030098589603300210","first-page":"569","volume":"377","author":"Cottier-Fox M","year":"1992","journal-title":"Progr Clin Biol Res"},{"key":"bibr10-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01952.x"},{"key":"bibr11-030098589603300210","first-page":"93","volume-title":"Diagnostic Cytology of the Dog and Cat","author":"Duncan JR","year":"1989"},{"key":"bibr12-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9975(92)90058-3"},{"key":"bibr13-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2427(87)90001-8"},{"key":"bibr14-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<480::AID-CNCR2820660314>3.0.CO;2-X"},{"key":"bibr15-030098589603300210","first-page":"172","volume":"113","author":"Harris NL","year":"1983","journal-title":"Am J Pathol"},{"key":"bibr16-030098589603300210","first-page":"733","volume":"35","author":"Ho CK","year":"1978","journal-title":"Immunology"},{"key":"bibr17-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/91.2.120"},{"key":"bibr18-030098589603300210","doi-asserted-by":"crossref","first-page":"491","DOI":"10.2460\/ajvr.1984.45.03.491","volume":"45","author":"Krawiec DR","year":"1984","journal-title":"Am J Vet Res"},{"key":"bibr19-030098589603300210","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2460\/ajvr.1984.45.03.499","volume":"45","author":"Krawiec DR","year":"1984","journal-title":"Am J Vet Res"},{"key":"bibr20-030098589603300210","first-page":"307","volume-title":"Differentiation Antigens in Lymphohemopoietic Tissues","author":"Ladiges WC","year":"1988"},{"key":"bibr21-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1089\/hyb.1984.3.387"},{"key":"bibr22-030098589603300210","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2460\/ajvr.1988.49.06.870","volume":"49","author":"Ladiges WC","year":"1988","journal-title":"Am J Vet Res"},{"key":"bibr23-030098589603300210","first-page":"895","volume":"29","author":"Levitt S","year":"1985","journal-title":"Acta Cytol"},{"key":"bibr24-030098589603300210","doi-asserted-by":"publisher","DOI":"10.3109\/10428198909042461"},{"key":"bibr25-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/82.6.666"},{"key":"bibr26-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.11.1194"},{"key":"bibr27-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198104000-00009"},{"key":"bibr28-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-5616(89)50079-2"},{"key":"bibr29-030098589603300210","first-page":"421","volume":"144","author":"Moore PF","year":"1994","journal-title":"Am J Pathol"},{"key":"bibr30-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1990.tb01831.x"},{"key":"bibr31-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1992.tb01963.x"},{"key":"bibr32-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1007\/BF00216700"},{"key":"bibr33-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02487.x"},{"key":"bibr34-030098589603300210","doi-asserted-by":"publisher","DOI":"10.3109\/00313028209092117"},{"key":"bibr35-030098589603300210","first-page":"47","volume-title":"TNM Classification of Tumours in Domestic Animals","author":"Owen LN","year":"1980"},{"key":"bibr36-030098589603300210","unstructured":"Perman V, Alasker RD, Riis RC: Cytology of the dog and cat, p. 13. American Animal Hospital Association, South Bend, IN, 1979."},{"key":"bibr37-030098589603300210","first-page":"181","volume":"128","author":"Picker LJ","year":"1987","journal-title":"Am J Pathol"},{"key":"bibr38-030098589603300210","first-page":"853","volume":"37","author":"Pilotti S","year":"1993","journal-title":"Acta Cytol"},{"key":"bibr39-030098589603300210","first-page":"62","volume":"8","author":"Ralfkiaer E","year":"1991","journal-title":"Semin Diagn Pathol"},{"key":"bibr40-030098589603300210","first-page":"453","volume":"31","author":"Robey SS","year":"1987","journal-title":"Acta Cytol"},{"key":"bibr41-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(92)90206-9"},{"key":"bibr42-030098589603300210","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/j.1600-0684.1986.tb00308.x","volume":"15","author":"Sandusky GE","year":"1986","journal-title":"J Med Primatol"},{"key":"bibr43-030098589603300210","first-page":"140","volume":"129","author":"Schuurman HJ","year":"1987","journal-title":"Lack of correlation between immunophenotype and cell morphology Am J Pathol"},{"key":"bibr44-030098589603300210","first-page":"12","volume":"1","author":"Skoog L","year":"1991","journal-title":"Diagn Oncol"},{"key":"bibr45-030098589603300210","first-page":"311","volume":"34","author":"Sneige N","year":"1990","journal-title":"Acta Cytol"},{"key":"bibr46-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1007\/BF00205629"},{"key":"bibr47-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.40.7.751"},{"key":"bibr48-030098589603300210","first-page":"209","volume":"32","author":"Tani EM","year":"1988","journal-title":"Acta Cytol"},{"key":"bibr49-030098589603300210","first-page":"363","volume":"33","author":"Tani EM","year":"1989","journal-title":"Acta Cytol"},{"key":"bibr50-030098589603300210","first-page":"19","author":"Teske E","year":"1993","journal-title":"Non-Hodgkin's Lymphoma in the Dog: Characterization and Experimental Therapy"},{"key":"bibr51-030098589603300210","first-page":"207","volume":"113","author":"Tubbs RR","year":"1983","journal-title":"Am J Pathol"},{"key":"bibr52-030098589603300210","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198206000-00010"},{"key":"bibr53-030098589603300210","first-page":"369","volume":"7","author":"Zander AR","year":"1975","journal-title":"Transplant Proc"},{"key":"bibr54-030098589603300210","first-page":"20","volume":"35","author":"Zinkl JG","year":"1981","journal-title":"Calif Vet"}],"container-title":["Veterinary Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589603300210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/030098589603300210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T19:35:58Z","timestamp":1777664158000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/030098589603300210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,3]]},"references-count":54,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1996,3]]}},"alternative-id":["10.1177\/030098589603300210"],"URL":"https:\/\/doi.org\/10.1177\/030098589603300210","relation":{},"ISSN":["0300-9858","1544-2217"],"issn-type":[{"value":"0300-9858","type":"print"},{"value":"1544-2217","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,3]]}}}