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Using regulatory documents, scientific publications, and media coverage, this article analyzes the making of this highly influential and mobile \u2018sex-difference fact\u2019. As we show, the FDA\u2019s decision was a contingent outcome of the drug approval process. Attending to how a contested sex-difference fact came to anchor elite women\u2019s health advocacy, this article excavates the role of regulatory processes, advocacy groups, and the media in producing perceptions of scientific agreement while foreclosing ongoing debate, ultimately enabling the stabilization of a binary, biological sex-difference fact and the distancing of this fact from its conditions of construction.<\/jats:p>","DOI":"10.1177\/03063127231168371","type":"journal-article","created":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T07:32:01Z","timestamp":1683358321000},"page":"475-494","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":30,"title":["Making a \u2018sex-difference fact\u2019: Ambien dosing at the interface of policy, regulation, women\u2019s health, and biology"],"prefix":"10.1177","volume":"53","author":[{"given":"Helen","family":"Zhao","sequence":"first","affiliation":[{"name":"Columbia University, New York, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"DiMarco","sequence":"additional","affiliation":[{"name":"University of Pittsburgh, Pittsburgh, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelsey","family":"Ichikawa","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Boulicault","sequence":"additional","affiliation":[{"name":"Massachusetts Institute of Technology, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meg","family":"Perret","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Jillson","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Fair","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"DeJesus","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah S.","family":"Richardson","sequence":"additional","affiliation":[{"name":"Harvard University, Cambridge, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2023,5,6]]},"reference":[{"key":"bibr1-03063127231168371","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.215"},{"key":"bibr2-03063127231168371","unstructured":"BioSpace. 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