{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:41:22Z","timestamp":1777376482716,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2000,4,1]],"date-time":"2000-04-01T00:00:00Z","timestamp":954547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2000,4]]},"abstract":"<jats:p>A 42-year-old female with von Willebrand's disease was managed with desmopressin and tranexamic acid to aid haemostasis following a vaginal hysterectomy. Severe acute hyponatraemia (134 to 108 mmol\/l) developed over two days, culminating in a generalized tonic-clonic seizure and cerebral oedema. Fluid restriction, cessation of desmopressin and hypertonic saline administration led to a full recovery. Desmopressin is known to reduce free water elimination and produce hyponatraemia, but its extent and rate of development in this patient was surprising. Close monitoring of serum sodium and fluid balance is recommended in these patients.<\/jats:p>","DOI":"10.1177\/0310057x0002800214","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T03:58:21Z","timestamp":1547611101000},"page":"199-201","source":"Crossref","is-referenced-by-count":33,"title":["Severe Hyponatraemia Secondary to Desmopressin Therapy in von Willebrand's Disease"],"prefix":"10.1177","volume":"28","author":[{"given":"D. M.","family":"Bertholini","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Townsville General Hospital, Townsville, Queensland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. S.","family":"Butler","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Townsville General Hospital, Townsville, Queensland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2000,4,1]]},"reference":[{"key":"bibr1-0310057X0002800214","first-page":"276","volume":"24","author":"Lusher J.M.","year":"1994","journal-title":"Haemostasis"},{"key":"bibr2-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807233390407"},{"key":"bibr3-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1007\/BF03005587"},{"key":"bibr4-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.7.2515"},{"key":"bibr5-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1981.tb02789.x"},{"key":"bibr6-0310057X0002800214","volume-title":"Review of Medical Physiology.","author":"Ganong W.F.","year":"1999","edition":"19"},{"key":"bibr7-0310057X0002800214","first-page":"597","volume":"282","author":"Bernat A.","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr8-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1975.tb00521.x"},{"key":"bibr9-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00070-X"},{"key":"bibr10-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)92806-Q"},{"key":"bibr11-0310057X0002800214","first-page":"203","volume":"44","author":"Bernstein S.A.","year":"1997","journal-title":"J Fam Pract"},{"key":"bibr12-0310057X0002800214","first-page":"79","volume":"87","author":"Mehta U.","year":"1997","journal-title":"S Afr Med J"},{"key":"bibr13-0310057X0002800214","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s004670050306","volume":"11","author":"Neuhaus T.J.","year":"1997","journal-title":"Pediatr Nephrol"},{"key":"bibr14-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.152.3.290"},{"key":"bibr15-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(77)91469-6"},{"key":"bibr16-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830320405"},{"key":"bibr17-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830440104"},{"key":"bibr18-0310057X0002800214","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80575-X"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0002800214","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0002800214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:05:01Z","timestamp":1777367101000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X0002800214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,4]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2000,4]]}},"alternative-id":["10.1177\/0310057X0002800214"],"URL":"https:\/\/doi.org\/10.1177\/0310057x0002800214","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,4]]}}}