{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:06:11Z","timestamp":1777377971673,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[2002,8,1]],"date-time":"2002-08-01T00:00:00Z","timestamp":1028160000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2002,8]]},"abstract":"<jats:p>This randomized controlled trial examined the effects of preoperative oral erythromycin or nizatidine on gastric pH and volume. Sixty patients, ASA 1 and 2 status scheduled for elective surgery were studied. All subjects received oral study medication with 10 ml of water 60 minutes prior to surgery. Patients in Group 1 (n=20) were given erythromycin 200 mg, in Group 2 (n=20) nizatidine 300 mg, and in Group 3 (n=20) placebo capsule. A nasogastric tube was inserted immediately after anaesthesia induction. Gastric content was aspirated, and volume and pH recorded.<\/jats:p>\n                  <jats:p>pH values determined in Group 1 were 5.6\u00b11.87; in Group 2, 5.65\u00b11.92 and in Group 3, 3.5\u00b11.93. There was no statistical difference between Groups 1 and 2, but there was a statistically significant difference between Group 3 and Groups 1 and 2 (P&lt;0.001). The volume of gastric content was 10.25\u00b16.65 ml in Group 1, 10.3\u00b16.29 ml in Group 2, and 20.25\u00b116.72 ml in Group 3. Again, there was no statistical difference between Groups 1 and 2, but there was a statistically significant difference between Group 3 and Groups 1 and 2 (P&lt;0.05). The proportion of patients considered \u201cat risk\u201d of significant lung injury should aspiration occur was 10% of Group 1, 5% of Group 2 and 20% of Group 3 (not statistically different).<\/jats:p>\n                  <jats:p>We conclude that oral erythromycin and nizatidine given one hour prior to surgery are effective in reducing gastric pH and volume.<\/jats:p>","DOI":"10.1177\/0310057x0203000404","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T20:45:48Z","timestamp":1548189948000},"page":"428-432","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Preoperative Oral Use of Erythromycin and Nizatidine on Gastric pH and Volume"],"prefix":"10.1177","volume":"30","author":[{"given":"D.","family":"Memis","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Reanimation and Department of Biostatistics, School of Medicine, Trakya University, Erdine, 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