{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T12:36:54Z","timestamp":1791031014145,"version":"4.1.0"},"reference-count":33,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T00:00:00Z","timestamp":1033430400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:p>\n                    The volatile anaesthetic agents are known to influence uterine muscle tone. All of the agents studied to date have been found to produce uterine relaxation. This property has been used to produce therapeutic uterine relaxation for difficult obstetric deliveries and the Ex Utero Intrapartum Treatment (EXIT) procedure. This study describes the effects of sevoflurane on isolated human myometrium at concentrations of 0.1, 0.25, 0.5, 0.75, 1.0, 1.5, 2.5 and 3.5 MAC. Sevoflurane produces dose-dependent depression of uterine muscle contractility with an ED\n                    <jats:sub>50<\/jats:sub>\n                    of 0.94 MAC. Frequency of contraction was increased at concentrations of 2.5 MAC and greater. At concentrations of 3.5 MAC and above, uterine activity was virtually abolished.\n                  <\/jats:p>","DOI":"10.1177\/0310057x0203000508","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T21:07:38Z","timestamp":1548191258000},"page":"591-596","source":"Crossref","is-referenced-by-count":41,"title":["The Effects of Sevoflurane on Isolated Gravid Human Myometrium"],"prefix":"10.1177","volume":"30","author":[{"given":"R. J.","family":"Turner","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"Lecturer, The University of New South Wales, Prince of Wales Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lambros","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"St George Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"The Canberra Hospital, Canberra, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. G.","family":"Katz","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"Director of Anaesthesia, Royal Hospital for Women, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. S.","family":"Downs","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"Visiting Medical Officer, Sydney Childrens Hospital, Royal Hospital for Women, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. W.","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"Sydney Children's Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. P.","family":"Gatt","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, NSW, Australia"},{"name":"Department of Anaesthesia, Prince of Wales Hospital, Sydney, Australia."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2002,10,1]]},"reference":[{"key":"bibr1-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198907000-00039"},{"key":"bibr2-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1007\/BF03008649"},{"key":"bibr3-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)90613-9"},{"key":"bibr4-0310057X0203000508","first-page":"416","volume":"92","author":"Dufour P.","year":"1998","journal-title":"Obstet Gynecol"},{"key":"bibr5-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70285-0"},{"key":"bibr6-0310057X0203000508","first-page":"824","volume":"93","author":"Liechty K.W.","year":"1999","journal-title":"Obstet Gynecol"},{"key":"bibr7-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197701000-00004"},{"key":"bibr8-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199936010-00002"},{"key":"bibr9-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199202000-00012"},{"key":"bibr10-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1007\/BF03010656"},{"key":"bibr11-0310057X0203000508","first-page":"725","volume-title":"Obstetric Anesthesia.","author":"Mayer D.C.","year":"1999"},{"key":"bibr12-0310057X0203000508","first-page":"74","volume-title":"Anesthetic and obstetric management of high-risk pregnancy.","author":"McMorland G.H.","year":"1991"},{"key":"bibr13-0310057X0203000508","first-page":"1844","volume":"42","author":"Takauchi Y.","year":"1993","journal-title":"Masui"},{"key":"bibr14-0310057X0203000508","first-page":"255","volume":"18","author":"Gregoriou O.","year":"1989","journal-title":"J Gynecol Obstet Biol Reprod (Paris)"},{"key":"bibr15-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1016\/S0750-7658(05)80275-8"},{"key":"bibr16-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00594-2"},{"key":"bibr17-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00006254-198403000-00002"},{"key":"bibr18-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197002000-00004"},{"key":"bibr19-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1967.tb03967.x"},{"key":"bibr20-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/42.2.136"},{"key":"bibr21-0310057X0203000508","first-page":"295","volume":"8","author":"Larsen M.E.","year":"1999","journal-title":"J Matern Fetal Med"},{"key":"bibr22-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199812000-00039"},{"key":"bibr23-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199705000-00039"},{"key":"bibr24-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8000800401"},{"key":"bibr25-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197701000-00005"},{"key":"bibr26-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1969.tb05847.x"},{"key":"bibr27-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-196609000-00014"},{"key":"bibr28-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1007\/BF03020420"},{"key":"bibr29-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1969.tb09446.x"},{"key":"bibr30-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199803000-00008"},{"key":"bibr31-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-200201000-00033"},{"key":"bibr32-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91593-2"},{"key":"bibr33-0310057X0203000508","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79332-3"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0203000508","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0203000508","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:09:45Z","timestamp":1777367385000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X0203000508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,10]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1177\/0310057X0203000508"],"URL":"https:\/\/doi.org\/10.1177\/0310057x0203000508","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,10]]}}}