{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:08:02Z","timestamp":1777378082700,"version":"3.51.4"},"reference-count":15,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2003,2,1]],"date-time":"2003-02-01T00:00:00Z","timestamp":1044057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2003,2]]},"abstract":"<jats:p>We describe the management of an 83-year-old woman who presented with upper airway obstruction due to angioedema of the tongue. Following definitive airway management, investigation showed a diagnosis of acquired C1 esterase inhibitor deficiency (acquired angioedema) that was considered to be subsequent to haematological malignancy. Resolution of the macroglossia followed treatment with C1 esterase inhibitor concentrate, but the patient failed to wean from ventilatory support and died in the Intensive Care Unit. This case report highlights the potential for acquired angioedema to cause upper airway obstruction. The various treatment modalities for acquired C1 esterase inhibitor deficiency are summarized.<\/jats:p>","DOI":"10.1177\/0310057x0303100120","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T14:33:37Z","timestamp":1547476417000},"page":"99-102","source":"Crossref","is-referenced-by-count":18,"title":["Angioedema of the Tongue Due to Acquired C1 Esterase Inhibitor Deficiency"],"prefix":"10.1177","volume":"31","author":[{"given":"G.","family":"Dobson","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, The Royal Hospital, Belfast, Northern Ireland.."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Edgar","sequence":"additional","affiliation":[{"name":"Regional Immunology Service, The Royal Hospitals, Belfast, Northern Ireland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Trinder","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, The Ulster Hospital, Belfast BT10 OTA, Northern Ireland."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2003,2,1]]},"reference":[{"key":"bibr1-0310057X0303100120","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4049\/jimmunol.118.6.2047","volume":"118","author":"Ziccardi R.J.","year":"1977","journal-title":"J Immunol"},{"key":"bibr2-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)61290-7"},{"key":"bibr3-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-2-200001180-00009"},{"key":"bibr4-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-188804000-00004"},{"key":"bibr5-0310057X0303100120","first-page":"39","volume":"1","author":"Caldwell J.R.","year":"1972","journal-title":"Clin Immunol"},{"key":"bibr6-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1986.tb13127.x"},{"key":"bibr7-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198502283120902"},{"key":"bibr8-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198705283162202"},{"key":"bibr9-0310057X0303100120","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1213\/00000539-199808000-00047","volume":"87","author":"Jensen N.F.","year":"1998","journal-title":"Anesth Analg"},{"key":"bibr10-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(75)90077-9"},{"key":"bibr11-0310057X0303100120","first-page":"793","volume":"30","author":"Carreer F.M.J.","year":"1992","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"bibr12-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1998.38698326333.x"},{"key":"bibr13-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1989.tb07774.x"},{"key":"bibr14-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80140-2"},{"key":"bibr15-0310057X0303100120","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(94)90380-8"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0303100120","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0303100120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:10:00Z","timestamp":1777367400000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X0303100120"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,2]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,2]]}},"alternative-id":["10.1177\/0310057X0303100120"],"URL":"https:\/\/doi.org\/10.1177\/0310057x0303100120","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,2]]}}}