{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:51:06Z","timestamp":1777377066597,"version":"3.51.4"},"reference-count":11,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:p>In sickle cell disease, cardiopulmonary bypass may induce red cell sickling. Partial exchange transfusion reduces the circulating haemoglobin S level. We report the management of a child with sickle cell disease who required surgical closure of a ventricular septal defect. Preoperative exchange transfusion of 50% of the total blood volume was performed with fresh packed red cells over three days. Further exchange transfusion was performed as cardiopulmonary bypass commenced. The haemoglobin S level was reduced from 76% to 37%. The blood removed from the patient during the exchanges was processed allowing storage and re-infusion of the patient's plasma and platelets. Combined preoperative and intraoperative exchange transfusions, instead of a single stage 50% volume exchange, was effective and potentially avoids larger haemodynamic effects. Cardiopulmonary bypass was conducted at normothermia and cold cardioplegia was avoided (fibrillatory arrest was used during the surgical repair).<\/jats:p>","DOI":"10.1177\/0310057x0703500524","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T22:16:01Z","timestamp":1548195361000},"page":"792-795","source":"Crossref","is-referenced-by-count":12,"title":["Perioperative Management of Sickle Cell Disease in Paediatric Cardiac Surgery"],"prefix":"10.1177","volume":"35","author":[{"given":"K.","family":"Bhatt","sequence":"first","affiliation":[{"name":"Departments of Cardiac Anaesthesiology and Critical Care Medicine, Frontier Lifeline, Chennai, India"},{"name":"Department of Cardiac Anaesthesiology."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Cherian","sequence":"additional","affiliation":[{"name":"Departments of Cardiac Anaesthesiology and Critical Care Medicine, Frontier Lifeline, Chennai, India"},{"name":"Department of Cardiac Surgery."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Departments of Cardiac Anaesthesiology and Critical Care Medicine, Frontier Lifeline, Chennai, India"},{"name":"Department of Cardiac Surgery."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Jose","sequence":"additional","affiliation":[{"name":"Departments of Cardiac Anaesthesiology and Critical Care Medicine, Frontier Lifeline, Chennai, India"},{"name":"Department of Perfusion Technology."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Cherian","sequence":"additional","affiliation":[{"name":"Departments of Cardiac Anaesthesiology and Critical Care Medicine, Frontier Lifeline, Chennai, India"},{"name":"Chairman and CEO, Chief Cardiac Surgeon, Frontier Lifeline."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2007,10,1]]},"reference":[{"key":"bibr1-0310057X0703500524","first-page":"1017","volume-title":"Miller's Anesthesia","author":"Roizean M.F.","year":"2005","edition":"6"},{"key":"bibr2-0310057X0703500524","first-page":"283","volume":"26","author":"Sutton S.W.","year":"1999","journal-title":"Tex Heart Inst J"},{"key":"bibr3-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1982.tb01109.x"},{"key":"bibr4-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1016\/S1053-0770(96)80108-X"},{"key":"bibr5-0310057X0703500524","first-page":"271","volume":"32","author":"Balasundaram S.","year":"1991","journal-title":"J Cardiovasc Surg (Torino)"},{"key":"bibr6-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei129"},{"key":"bibr7-0310057X0703500524","first-page":"765","volume-title":"Kaplan's cardiac anaesthesia","author":"Oliver W.C.","year":"2006","edition":"5"},{"key":"bibr8-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1016\/S0012-3692(15)52915-2"},{"key":"bibr9-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1016\/S1010-7940(98)00198-5"},{"key":"bibr10-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2005.02.037"},{"key":"bibr11-0310057X0703500524","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119631"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0703500524","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0703500524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:06:34Z","timestamp":1777367194000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X0703500524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1177\/0310057X0703500524"],"URL":"https:\/\/doi.org\/10.1177\/0310057x0703500524","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10]]}}}