{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:53:39Z","timestamp":1777377219466,"version":"3.51.4"},"reference-count":19,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2008,5,1]],"date-time":"2008-05-01T00:00:00Z","timestamp":1209600000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:p>\n                    The dosages and potency of intravenous mephentermine for prevention of post-spinal hypotension are not available in English literature. This study was designed to determine the minimum effective dose (ED\n                    <jats:sub>50<\/jats:sub>\n                    ) of mephentermine and to compare its potency with that of ephedrine for prevention of post-spinal hypotension in parturients undergoing caesarean section. Dixon's up-down method of sequential allocation was used for vasopressor doses. Following administration of spinal anaesthesia, patients received a prophylactic infusion with 50 mg infused over a period of 30 minutes as the initial dose and dose intervals of 5 mg, of either ephedrine or mephentermine. The ED\n                    <jats:sub>50<\/jats:sub>\n                    of ephedrine was 25.0 mg (95% CI 15.5 to 40.4 mg). For mephentermine, the up-down method was abandoned due to the success of the minimum dose possible but the ED\n                    <jats:sub>50<\/jats:sub>\n                    appeared to be less than 5 mg. In conclusion, the minimum effective dose of mephentermine is much less than that of ephedrine for prevention of post-spinal hypotension. Another trial with a lower starting dose and smaller dose interval of mephentermine is required to determine the potency ratio of mephentermine and ephedrine.\n                  <\/jats:p>","DOI":"10.1177\/0310057x0803600306","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T04:16:37Z","timestamp":1547612197000},"page":"360-364","source":"Crossref","is-referenced-by-count":7,"title":["Comparison of Potency of Ephedrine and Mephentermine for Prevention of Post-Spinal Hypotension in Caesarean Section"],"prefix":"10.1177","volume":"36","author":[{"given":"M.","family":"Mohta","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Tyagi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. K.","family":"Sethi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Critical Care, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2008,5,1]]},"reference":[{"key":"bibr1-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2001.02058-5.x"},{"key":"bibr2-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200201000-00010"},{"key":"bibr3-0310057X0803600306","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1213\/00000539-200002000-00016","volume":"90","author":"Vercauteren M.P.","year":"2000","journal-title":"Anesth Analg"},{"key":"bibr4-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/76.1.61"},{"key":"bibr5-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200108000-00009"},{"key":"bibr6-0310057X0803600306","first-page":"217","volume":"100","author":"Lauckner W.","year":"1978","journal-title":"Zentralblatt fur Gynakologie"},{"key":"bibr7-0310057X0803600306","unstructured":"Mephentine\u2014prescribing information. From: http:\/\/www.wyethindia.com Accessed September 2007."},{"key":"bibr8-0310057X0803600306","first-page":"125","volume":"47","author":"Sahu D.","year":"2003","journal-title":"Indian Journal of Anaesthesia"},{"key":"bibr9-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2004.03994.x"},{"key":"bibr10-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei265"},{"key":"bibr11-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1965.10480843"},{"key":"bibr12-0310057X0803600306","unstructured":"DixonW.J., MasseyF.J. Introduction to statistical analysis, 4th Ed. New York: McGraw Hill 1983. p 426\u2013441."},{"key":"bibr13-0310057X0803600306","first-page":"290","volume":"139","author":"Zimmerman B.G.","year":"1963","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr14-0310057X0803600306","first-page":"364","volume":"112","author":"Glassman J.M.","year":"1954","journal-title":"J Pharmacol Exp Ther"},{"key":"bibr15-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/75.3.262"},{"key":"bibr16-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199608000-00017"},{"key":"bibr17-0310057X0803600306","first-page":"237","volume-title":"Goodman & Gilman's The pharmacological basis of therapeutics","author":"Westfall T.C.","year":"2006","edition":"11"},{"key":"bibr18-0310057X0803600306","doi-asserted-by":"publisher","DOI":"10.1007\/s002280100317"},{"key":"bibr19-0310057X0803600306","first-page":"542","volume-title":"Medical Toxicology,","author":"Lieberman D.E.","year":"2004","edition":"3"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0803600306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X0803600306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:07:00Z","timestamp":1777367220000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X0803600306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,5]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,5]]}},"alternative-id":["10.1177\/0310057X0803600306"],"URL":"https:\/\/doi.org\/10.1177\/0310057x0803600306","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,5]]}}}