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Its antimicrobial effects persist because it is binds strongly to proteins in the skin and mucosa, making it an effective antiseptic ingredient for handwashing, skin preparation for surgery and the placement of intravascular access. Catheters impregnated with chlorhexidine and antimicrobial agents can reduce the incidence of catheter-related bloodstream infections. Contact dermatitis related to chlorhexidine is not common in health care workers. The incidence of contact dermatitis to chlorhexidine in atopic patients is approximately 2.5 to 5.4%. Acute hypersensitivity reactions to chlorhexidine are often not recognised and therefore may be underreported. This review discusses the pharmacology, microbiology, clinical applications and adverse effects of chlorhexidine.<\/jats:p>","DOI":"10.1177\/0310057x0803600404","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T17:35:11Z","timestamp":1547487311000},"page":"502-512","source":"Crossref","is-referenced-by-count":222,"title":["Chlorhexidine - Pharmacology and Clinical Applications"],"prefix":"10.1177","volume":"36","author":[{"given":"K. -S.","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"},{"name":"Department of Anaesthetics, University of Sydney, Repatriation General Hospital Concord."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.C.A.","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Anaesthetics, University of Sydney, Royal Prince Alfred Hospital, Sydney, New South Wales, 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