{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T02:06:55Z","timestamp":1787018815342,"version":"build-2736575974"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>\n                    Malignant hyperthermia is a pharmacogenetic skeletal muscle disorder of intracellular calcium (Ca\n                    <jats:sup>2+<\/jats:sup>\n                    ) homeostasis with an autosomal dominant inheritance. The objective of this study was to investigate the safety of propofol by investigating its effects on calcium homeostasis and its effect sites in human skeletal muscles.\n                  <\/jats:p>\n                  <jats:p>\n                    Muscle specimens were obtained from 10 individuals with predisposition to malignant hyperthermia. In skinned fibre experiments, we measured the effects of propofol on the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release and the uptake of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    into the sarcoplasmic reticulum. Ca\n                    <jats:sup>2+<\/jats:sup>\n                    imaging in primary myotubes was employed to analyse propofol-mediated alternations in the Ca\n                    <jats:sup>2+<\/jats:sup>\n                    regulation and propofol-induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    responses in the presence of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blocker or Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release inhibitor.\n                  <\/jats:p>\n                  <jats:p>\n                    Increased Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release from the sarcoplasmic reticulum and inhibition of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    uptake into the sarcoplasmic reticulum were not observed with 100 \u03bcM propofol. A rise of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    was not seen under 100 \u03bcM propofol and the EC\n                    <jats:sub>50<\/jats:sub>\n                    value for propofol was 274.7\u00b133.9 \u03bcM, which, is higher than the clinical levels for anaesthesia. Propofol-induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    responses were remarkably attenuated in the presence of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channel blocker or Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -induced Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release inhibitor compared with the results obtained with caffeine.\n                  <\/jats:p>\n                  <jats:p>We conclude firstly that propofol is safe for individuals with predisposition to malignant hyperthermia when it is used within the recommended clinical dosage range, and secondly that its mode of action upon ryanodine receptors is likely to be different from that of caffeine.<\/jats:p>","DOI":"10.1177\/0310057x0903700313","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T17:36:48Z","timestamp":1547487408000},"page":"415-425","source":"Crossref","is-referenced-by-count":10,"title":["Effects of Propofol on Calcium Homeostasis in Human Skeletal Muscle"],"prefix":"10.1177","volume":"37","author":[{"given":"T.","family":"Migita","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Mukaida","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan"},{"name":"Division of Anesthesia, Hiroshima Prefectural Rehabilitation Center."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Hamada","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan"},{"name":"Department of Anesthesia, Hiroshima City Funairi Hospital."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan"},{"name":"Department of Neuromuscular Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Yuge","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, Japan"},{"name":"Hiroshima University."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Kawamoto","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care, Hiroshima University, Hiroshima, 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