{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:59:00Z","timestamp":1777377540606,"version":"3.51.4"},"reference-count":18,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2013,9]]},"abstract":"<jats:p>Lipid emulsions have been used to treat cardiovascular collapse due to local anaesthetic toxicity. However, there are few data available on the comparative efficiency of the partitioning properties of available lipid emulsions in clinical use. This in vitro study compared the buffering properties of the lipid emulsions Clinoleic\u2122 20% (Baxter, Old Toongabbie, NSW) and Intralipid\u00ae 20% (Fresenius Kabi, Pymble, NSW) using both bupivacaine (Marcain\u00ae 0.5%, AstraZeneca, North Ryde, NSW) and ropivacaine (Naropin\u00ae 1%, AstraZeneca, North Ryde, NSW). The concentration of anaesthetic in buffer before and after mixing with lipid was quantified using chromatographic analysis. Bupivacaine was more effectively bound by the lipid agents, with a 40% reduction in initial concentration. Ropivacaine demonstrated a 20% reduction in concentration with the addition of lipid agents. Importantly, there was no significant difference between Intralipid and Clinoleic in terms of their buffering behaviour, suggesting equivalent binding efficacy.<\/jats:p>","DOI":"10.1177\/0310057x1304100507","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T17:42:16Z","timestamp":1547487736000},"page":"618-622","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Binding of Local Anaesthetics to the Lipid Emulsion Clinoleic\n                    <sup>\u2122<\/sup>\n                    20%"],"prefix":"10.1177","volume":"41","author":[{"given":"J. A.","family":"Evans","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. C.","family":"Wallis","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia"},{"name":"Burns Trauma and Critical Care Research Centre, University of Queensland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"Dulhunty","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia"},{"name":"Department of Intensive Care Medicine, Royal Brisbane and Women's Hospital; and Burns, Trauma and Critical Care Research Centre, University of Queensland."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Pang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Brisbane, Queensland, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2013,9,1]]},"reference":[{"key":"bibr1-0310057X1304100507","volume-title":"Emergencies in Anaesthesia","author":"Allman K.","year":"2006"},{"key":"bibr2-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2005.04494.x"},{"key":"bibr3-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1097\/00115550-200305000-00005"},{"key":"bibr4-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2009.05893.x"},{"key":"bibr5-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199804000-00028"},{"key":"bibr6-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2011.10.008"},{"key":"bibr7-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200607000-00033"},{"key":"bibr8-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2007.05065.x"},{"key":"bibr9-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318194b252"},{"key":"bibr10-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2012.07056.x"},{"key":"bibr11-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/66.1.25"},{"key":"bibr12-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/59.11.1425"},{"key":"bibr13-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/58.7.717"},{"key":"bibr14-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1986.tb13171.x"},{"key":"bibr15-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1097\/01.mco.0000214563.21697.55"},{"key":"bibr16-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e32802bf787"},{"key":"bibr17-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1177\/0148607100024002113"},{"key":"bibr18-0310057X1304100507","doi-asserted-by":"publisher","DOI":"10.1054\/clnu.1999.0076"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X1304100507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X1304100507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:07:54Z","timestamp":1777367274000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X1304100507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["10.1177\/0310057X1304100507"],"URL":"https:\/\/doi.org\/10.1177\/0310057x1304100507","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,9]]}}}