{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:26:00Z","timestamp":1791257160157,"version":"4.1.0"},"reference-count":45,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2013,11]]},"abstract":"<jats:p>\n                    Anaphylactic shock is a rare, but potentially lethal complication, combining life-threatening circulatory failure and massive fluid shifts. Treatment guidelines rely on adrenaline and volume expansion by intravenous fluids, but there is no solid evidence for the choice of one specific type of fluid over another. Our purpose was to compare the time to achieve target mean arterial pressure upon resuscitation using adrenaline alone versus adrenaline with different resuscitation fluids in an animal model and to compare the tissue oxygen pressures (PtiO\n                    <jats:sub>2<\/jats:sub>\n                    ) with the various strategies. Twenty-five ovalbumin-sensitised Brown Norway rats were allocated to five groups after anaphylactic shock induction: vehicle (CON), adrenaline alone (AD), or adrenaline with isotonic saline (AD+IS), hydroxyethyl starch (AD+HES) or hypertonic saline (AD+HS). Time to reach a target mean arterial pressure value of 75 mmHg, cardiac output, skeletal muscle PtiO\n                    <jats:sub>2<\/jats:sub>\n                    , lactate\/pyruvate ratio and cumulative doses of adrenaline were recorded. Non-treated rats died within 15 minutes. The target mean arterial pressure value was reached faster with AD+HES (median: 10 minutes, range: 7.5 to 12.5 minutes) and AD+IS (median: 17.5 minutes, range: 5 to 25 minutes) versus adrenaline alone (median: 25 minutes, range: 20\u201330 minutes). There were also reduced adrenaline requirements in these groups. The skeletal muscle PtiO\n                    <jats:sub>2<\/jats:sub>\n                    was restored only in the AD+HES group. Although direct extrapolation to humans should be made with caution, our results support the combined use of adrenaline and volume expansion for resuscitation from anaphylactic shock. When used with adrenaline the most effective fluid was hydroxyethyl starch, whereas hypertonic saline was the least effective.\n                  <\/jats:p>","DOI":"10.1177\/0310057x1304100612","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T04:29:32Z","timestamp":1547612972000},"page":"765-773","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":19,"title":["Time to Achieve Target Mean Arterial Pressure during Resuscitation from Experimental Anaphylactic Shock in an Animal Model. A Comparison of Adrenaline Alone or in Combination with Different Volume Expanders"],"prefix":"10.1177","volume":"41","author":[{"given":"K.","family":"Tajima","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"Universit\u00e9 de Lorraine, Vand\u0153uvre-l\u00e8s-Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Zheng","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"Universit\u00e9 de Lorraine, Vand\u0153uvre-l\u00e8s-Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Collange","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"\u00e9animations Chirurgicales, SAMU, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Barthel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"Universit\u00e9 de Lorraine, Vand\u0153uvre-l\u00e8s-Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. N.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"Universit\u00e9 de Lorraine, Vand\u0153uvre-l\u00e8s-Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Longrois","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation Chirurgicale, H\u00f4pital Bichat-Claude Bernard, Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Levy","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"Service de R\u00e9animation M\u00e9dicale, Institut Lorrain du Coeur et des Vaisseaux, Vandoeuvre-l\u00e8s-Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Audibert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation Chirurgicale, Centre Hospitalier Universitaire (CHU) Central, Nancy, France."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Malinovsky","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"D\u00e9partement d'Anesth\u00e9sie-R\u00e9animation Chirurgicale, CHU de Reims, Reims, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. M.","family":"Mertes","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Groupe choc, U1116 Inserm, University of Lorraine, Vandoeuvre-l\u00e8s-Nancy, France"},{"name":"P\u00f4le Anesth\u00e9sie, R\u00e9animations Chirurgicales, SAMU, H\u00f4pitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2013,11,1]]},"reference":[{"key":"bibr1-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200507000-00010"},{"key":"bibr2-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e3182690897"},{"key":"bibr3-0310057X1304100612","first-page":"442","volume":"21","author":"Mertes P.M.","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"bibr4-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01523.x"},{"key":"bibr5-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.2008.05733.x"},{"key":"bibr6-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1179\/acb.2007.092"},{"key":"bibr7-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181770b42"},{"key":"bibr8-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/01.CCM.0000186770.59312.44"},{"key":"bibr9-0310057X1304100612","first-page":"266","volume":"59","author":"Homma H.","year":"2005","journal-title":"J Trauma"},{"key":"bibr10-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00864.x"},{"key":"bibr11-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200604000-00018"},{"key":"bibr12-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.06.022"},{"key":"bibr13-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/87.4.549"},{"key":"bibr14-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2011.03.003"},{"key":"bibr15-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1186\/cc11358"},{"key":"bibr16-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.2007.01313.x"},{"key":"bibr17-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8601400105"},{"key":"bibr18-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1209759"},{"key":"bibr19-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2011.10.003"},{"key":"bibr20-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318173f982"},{"key":"bibr21-0310057X1304100612","first-page":"291","volume":"124","author":"Sun H.J.","year":"2011","journal-title":"Chin Med J (Engl)"},{"key":"bibr22-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e318186ff48"},{"key":"bibr23-0310057X1304100612","first-page":"408","volume":"23","author":"Braun L.I.B.","year":"1925","journal-title":"S Afr Med Rec"},{"key":"bibr24-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/01.all.0000174158.78626.35"},{"key":"bibr25-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2010.04.002"},{"key":"bibr26-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1177\/03946320110240S314"},{"key":"bibr27-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2005.07.001"},{"key":"bibr28-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1067\/mhj.2002.123146"},{"key":"bibr29-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043046"},{"key":"bibr30-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000122639.55433.06"},{"key":"bibr31-0310057X1304100612","first-page":"275","volume":"71","author":"Gong W.","year":"2011","journal-title":"J Trauma"},{"key":"bibr32-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181c4a5e2"},{"key":"bibr33-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00005373-199101000-00002"},{"key":"bibr34-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198903000-00012"},{"key":"bibr35-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/MCC.0b013e328355598c"},{"key":"bibr36-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200011000-00005"},{"key":"bibr37-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00492.2007"},{"key":"bibr38-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2006.00395.x"},{"key":"bibr39-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.2741\/3106"},{"key":"bibr40-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-121996"},{"key":"bibr41-0310057X1304100612","first-page":"1299","volume":"25","author":"Zheng M.","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"bibr42-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1971.220.2.384"},{"key":"bibr43-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199506000-00010"},{"key":"bibr44-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199910000-00014"},{"key":"bibr45-0310057X1304100612","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199708000-00006"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X1304100612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X1304100612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:07:59Z","timestamp":1777367279000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X1304100612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,11]]},"references-count":45,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["10.1177\/0310057X1304100612"],"URL":"https:\/\/doi.org\/10.1177\/0310057x1304100612","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,11]]}}}