{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T18:42:11Z","timestamp":1791484931560,"version":"4.3.4"},"reference-count":12,"publisher":"SAGE Publications","issue":"2","license":[{"start":{"date-parts":[[2014,3,1]],"date-time":"2014-03-01T00:00:00Z","timestamp":1393632000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2014,3]]},"abstract":"\n The aim of this study was to investigate the effects of different general anaesthesia techniques on immune responses in patients undergoing surgery for tongue cancer. Sixty American Society of Anesthesiologists physical status 1 or 2 patients undergoing elective reconstructive surgery for tongue cancer were randomised to three groups. Group 1 received propofol induction and maintenance (TIVA), group 2 received propofol induction and sevoflurane maintenance (MIXED) and group 3 received sevoflurane induction and maintenance (SEVO). All patients received an infusion of remifentanil. Blood samples were obtained at eight time-points: 30 minutes before induction (T\n 0<\/jats:sub>\n ); one hour (T\n 1<\/jats:sub>\n ), three hours (T\n 2<\/jats:sub>\n ) and five hours (T\n 3<\/jats:sub>\n ) after induction; at the end of the operation (T\n 4<\/jats:sub>\n ); and 24 hours (T\n 3<\/jats:sub>\n ), 48 hours (T\n 6<\/jats:sub>\n ) and 72 hours (T\n 7<\/jats:sub>\n ) after operation. The T lymphocyte subsets (including CD3\n +<\/jats:sup>\n cells, CD3\n +<\/jats:sup>\n CD4\n +<\/jats:sup>\n cells and CD3\n +<\/jats:sup>\n CD8\n +<\/jats:sup>\n cells) and CD4\n +<\/jats:sup>\n \/CD8\n +<\/jats:sup>\n ratio, natural killer cells and B lymphocytes were analysed by flow cytometry. All immunological indicators except CD3\n +<\/jats:sup>\n CD8\n +<\/jats:sup>\n cells were significantly decreased in all groups at T\n 1<\/jats:sub>\n \u223cT\n 5<\/jats:sub>\n compared to T\n 0<\/jats:sub>\n ( P <0.05). The percentages of CD3\n +<\/jats:sup>\n cells, CD3\/ CD4\n +<\/jats:sup>\n cells and natural killer cells, and the CD4\/CD8+ ratios were significantly lower in the MIXED groups and SEVO groups but not the TIVA group at T\n 6<\/jats:sub>\n as compared with T\n 0<\/jats:sub>\n ( P <0.05). There were minor but statistically significant differences in the percentages of CD3\n +<\/jats:sup>\n cells, CD3\n +<\/jats:sup>\n CD4\n +<\/jats:sup>\n cells and natural killer cells, and the CD4\/CD8\n +<\/jats:sup>\n ratios between the SEVO group and the TIVA group at T\n 2<\/jats:sub>\n \u223cT\n 6<\/jats:sub>\n ( P <0.05). These findings suggest that propofol has slightly less effect on cellular immune responses than sevoflurane.\n <\/jats:p>","DOI":"10.1177\/0310057x1404200209","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T04:31:30Z","timestamp":1547613090000},"page":"220-227","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":37,"title":["Effects of Different General Anaesthetic Techniques on Immune Responses in Patients Undergoing Surgery for Tongue Cancer"],"prefix":"10.1177","volume":"42","author":[{"given":"T.","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and The State Key Laboratory Breeding Base of Basic Sciene of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and The State Key Laboratory Breeding Base of Basic Sciene of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China"},{"name":"Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and The State Key Laboratory Breeding Base of Basic Sciene of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and The State Key Laboratory Breeding Base of Basic Sciene of Stomatology (Hubei-MOST) and Key Laboratory for Oral Biomedicine, Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China"},{"name":"Department of Anesthesiology, Zhongnan Hospital, Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2014,3,1]]},"reference":[{"key":"bibr1-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2010.07.011"},{"key":"bibr2-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-008-0626-2"},{"key":"bibr3-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000082995.44040.07"},{"key":"bibr4-0310057X1404200209","first-page":"523","volume":"54","author":"Vali\u00e9n J.L.","year":"2007","journal-title":"Rev Esp Anestesiol Reanim"},{"key":"bibr5-0310057X1404200209","first-page":"284","volume":"30","author":"Xing C.Y.","year":"2010","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"bibr6-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199505183322008"},{"key":"bibr7-0310057X1404200209","first-page":"205","volume":"50","author":"Kennedy B.C.","year":"1999","journal-title":"Acta Anaesthesiol Belg"},{"key":"bibr8-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1615\/JEnvPathToxOncol.v22.i2.70"},{"key":"bibr9-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1097\/SLA.0b013e318211d7b5"},{"key":"bibr10-0310057X1404200209","first-page":"968","volume":"57","author":"Kitamura T.","year":"2008","journal-title":"Masui"},{"key":"bibr11-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1159\/000012090"},{"key":"bibr12-0310057X1404200209","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.06.027"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X1404200209","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X1404200209","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:08:10Z","timestamp":1777367290000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X1404200209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,3]]}},"alternative-id":["10.1177\/0310057X1404200209"],"URL":"https:\/\/doi.org\/10.1177\/0310057x1404200209","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,3]]}}}