{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:04:24Z","timestamp":1777377864885,"version":"3.51.4"},"reference-count":35,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:p>\n                    Interscalene blockade (ISB) is commonly associated with Horner's syndrome, indicating spread of injectate to the cervical sympathetic chain. Cervical sympathetic nerve activity (SNA) is believed to influence cerebral autoregulation, and a decrease in sympathetic tone may alter cerebral blood flow (CBF). This study investigated whether ISB influenced CBF in patients undergoing shoulder surgery. Patients (n=30) scheduled for elective shoulder arthroscopy were recruited. Cerebral oxygen saturation (ScO\n                    <jats:sub>2<\/jats:sub>\n                    ) of the left and right frontal cortices was continuously measured during ISB administration, sedation and anaesthetic induction. Baseline ScO\n                    <jats:sub>2<\/jats:sub>\n                    was similar in blocked and unblocked sides (74 \u00b1 5% and 73 \u00b1 5% respectively, P=0.70). ScO\n                    <jats:sub>2<\/jats:sub>\n                    decreased with sedation (-3 \u00b1 3% and \u22124 \u00b1 3%, P=0.93), and increased with pre-oxygenation and general anaesthesia ( P &lt;0.01). Following ISB there was no change in ScO\n                    <jats:sub>2<\/jats:sub>\n                    between blocked and unblocked sides ( P=0.18), or any difference between right- or left-sided ISB. ISB is not associated with an increase in CBF as indicated by ScO\n                    <jats:sub>2<\/jats:sub>\n                    , despite the presence of Horner's syndrome.\n                  <\/jats:p>","DOI":"10.1177\/0310057x1604400301","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T00:42:54Z","timestamp":1548204174000},"page":"359-363","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Interscalene Anaesthesia on Cerebral Oxygen Saturation"],"prefix":"10.1177","volume":"44","author":[{"given":"P. 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