{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T18:47:06Z","timestamp":1788115626123,"version":"build-2803163510"},"reference-count":32,"publisher":"SAGE Publications","issue":"5","license":[{"start":{"date-parts":[[2022,6,19]],"date-time":"2022-06-19T00:00:00Z","timestamp":1655596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:p>The ROTEM\u00aedelta (TEM Innovations GmbH, Munich, Germany) has been used extensively worldwide for the assessment of coagulation in cardiac surgical patients. Recently, a new cartridge-based ROTEM device (ROTEM\u00aesigma, TEM Innovations GmbH, Munich, Germany) has become available. In this paper we report an audit of the diagnostic accuracy of the ROTEM sigma for the identification of hypofibrinogenaemia in cardiac surgical patients. We hypothesised that the diagnostic accuracy of the ROTEMsigma for the identification of hypofibrinogenaemia would be in a similar range to that previously reported for the ROTEMdelta. Simultaneous blood samples for Clauss laboratory fibrinogen and ROTEMsigma FIBTEM measurements were obtained immediately after heparin reversal post-cardiopulmonary bypass in 200 adult cardiac surgical patients. The sensitivity, specificity, and positive and negative predictive values for FIBTEM A5 and A10 for the identification of hypofibrinogenaemia (Clauss fibrinogen &lt;1.5\u2009g\/l) were calculated. The prevalence of hypofibrinogenaemia across the 200 patients was 8%. The mean sensitivity and specificity of FIBTEM A10 \u22648\u2009mm for the identification of hypofibrinogenaemia were 0.75 and 0.90 respectively, which are in a similar range to that reported in several previous studies using the ROTEMdelta. For FIBTEM A5 \u22646\u2009mm the values were 0.63 and 0.98 respectively. The predictive values were also in a similar range to those previously reported for the ROTEMdelta, with low false negative rates (2% for A10 \u22648\u2009mm; 3% for A5 \u22646\u2009mm). These findings support the use of the ROTEMsigma as an alternative to the ROTEMdelta for the identification of hypofibrinogenaemia post-cardiopulmonary bypass in cardiac surgical patients. However, further studies are required in other settings.<\/jats:p>","DOI":"10.1177\/0310057x211067807","type":"journal-article","created":{"date-parts":[[2022,6,20]],"date-time":"2022-06-20T01:09:20Z","timestamp":1655687360000},"page":"388-395","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["An audit of the diagnostic accuracy of the ROTEM\u00aesigma for the identification of hypofibrinogenaemia in cardiac surgical patients"],"prefix":"10.1177","volume":"50","author":[{"given":"Shannon","family":"A Matzelle","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Sir Charles Gairdner Hospital, Australia"},{"name":"Department of Anaesthesia, St John of God Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"F Preuss","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Sir Charles Gairdner Hospital, Australia"},{"name":"Department of Anaesthesia, St John of God Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"M Weightman","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Sir Charles Gairdner Hospital, Australia"},{"name":"Department of Anaesthesia, St John of God Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3487-6452","authenticated-orcid":false,"given":"Neville","family":"M Gibbs","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Sir Charles Gairdner Hospital, Australia"},{"name":"Department of Anaesthesia, St John of God Hospital, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2022,6,19]]},"reference":[{"key":"bibr1-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2012.06.015"},{"key":"bibr2-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2016.03.008"},{"key":"bibr3-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex100"},{"key":"bibr4-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23599"},{"key":"bibr5-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivt506"},{"key":"bibr6-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/anae.12898"},{"key":"bibr7-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2016.01.005"},{"key":"bibr8-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aev539"},{"key":"bibr9-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14842"},{"key":"bibr10-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14542"},{"key":"bibr11-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2019.1571220"},{"key":"bibr12-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2019.10.016"},{"key":"bibr13-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X20948868"},{"key":"bibr14-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/anae.14711"},{"key":"bibr15-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5527"},{"key":"bibr16-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04256.x"},{"key":"bibr17-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13580"},{"key":"bibr18-0310057X211067807","unstructured":"National Institute for Health and Care Excellence.\n                      Blood Transfusion\n                      . NICE guideline [NG24], www.nice.org.uk\/guidance\/ng24 (2015, accessed September 2021)."},{"key":"bibr19-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/anae.13489"},{"key":"bibr20-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezx325"},{"key":"bibr21-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000630"},{"key":"bibr22-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X1804600614"},{"key":"bibr23-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12988"},{"key":"bibr24-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2010.11.020"},{"key":"bibr25-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004522"},{"key":"bibr26-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2015.04.030"},{"key":"bibr27-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1007\/s00068-019-01165-7"},{"key":"bibr28-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181966675"},{"key":"bibr29-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201647"},{"key":"bibr30-0310057X211067807","volume-title":"Diagnostic test toolkit","author":"Thompson M","year":"2012","edition":"2"},{"key":"bibr31-0310057X211067807","unstructured":"US Department of Health and Human Services Food and Drug Administration. Statistical guidance on reporting results from studies evaluating diagnostic tests: guidance for industry and FDA staff, www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/statistical-guidance-reporting-results-studies-evaluating-diagnostic-tests-guidance-industry-and-fda (2007, accessed May 2021)."},{"key":"bibr32-0310057X211067807","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2012.182543"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X211067807","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0310057X211067807","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X211067807","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:12:28Z","timestamp":1777367548000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X211067807"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,19]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1177\/0310057X211067807"],"URL":"https:\/\/doi.org\/10.1177\/0310057x211067807","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,19]]}}}