{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:21:22Z","timestamp":1777378882097,"version":"3.51.4"},"reference-count":27,"publisher":"SAGE Publications","issue":"1","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:p>Vasopressor dependence is a common problem affecting patients in the recovery phase of critical illness, often necessitating intensive care unit (ICU) admission and other interventions which carry associated risks. Midodrine is an orally administered vasopressor which is commonly used off-label to expedite weaning from vasopressor infusions and facilitate discharge from ICU. We performed a single-centre, case-control study to assess whether midodrine accelerated liberation from vasopressor infusions in patients who were vasopressor dependent. Cases were identified at the discretion of treating intensivists and received 20\u2009mg oral midodrine every eight h from enrolment. Controls received placebo. Data on duration and dose of vasopressor infusion, haemodynamics and adverse events were collected. Between 2012 and 2019, 42 controls and 19 cases were recruited. Cases had received vasopressor infusions for a median of 94\u2009h versus 29.3\u2009h for controls, indicating prolonged vasopressor dependence amongst cases. Midodrine use in cases was not associated with faster weaning of intravenous (IV) vasopressors (26\u2009h versus 24 h for controls, P\u2009=\u20090.51), ICU or hospital length of stay after adjustment for confounders. Midodrine did not affect mean heart rate but was associated with bradycardia. This case-control study demonstrates that midodrine has limited efficacy in expediting weaning from vasopressor infusions in patients who have already received relatively prolonged courses of these infusions.<\/jats:p>","DOI":"10.1177\/0310057x221105297","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T03:10:36Z","timestamp":1664334636000},"page":"20-28","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":10,"title":["Oral midodrine does not expedite liberation from protracted vasopressor infusions: A case-control study"],"prefix":"10.1177","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7819-0447","authenticated-orcid":false,"given":"Alexander JT","family":"Wood","sequence":"first","affiliation":[{"name":"Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia"},{"name":"University of Western Australia, School of Medicine, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-2305","authenticated-orcid":false,"given":"Rashmi","family":"Rauniyar","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Jacques","sequence":"additional","affiliation":[{"name":"Institute for Health Research, The University of Notre Dame Australia, Fremantle, Australia"},{"name":"Department of Research, Sir Charles Gairdner Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert N","family":"Palmer","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley","family":"Wibrow","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia"},{"name":"University of Western Australia, School of Medicine, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7927-524X","authenticated-orcid":false,"given":"Matthew H","family":"Anstey","sequence":"additional","affiliation":[{"name":"Intensive Care Department, Sir Charles Gairdner Hospital, Perth, Australia"},{"name":"University of Western Australia, School of Medicine, Perth, Australia"},{"name":"Curtin University, School of Public Health, Perth, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"bibr1-0310057X221105297","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.02.657"},{"key":"bibr2-0310057X221105297","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500964"},{"key":"bibr3-0310057X221105297","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03553-1"},{"key":"bibr4-0310057X221105297","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X20984794"},{"key":"bibr5-0310057X221105297","first-page":"31","volume":"44","author":"Australian Prescriber","year":"2021","journal-title":"Aust Prescr"},{"key":"bibr6-0310057X221105297","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrc.2013.05.021"},{"key":"bibr7-0310057X221105297","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06216-x"},{"key":"bibr8-0310057X221105297","unstructured":"RStudio Team. 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