{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T22:27:14Z","timestamp":1793917634983,"version":"4.8.0"},"reference-count":76,"publisher":"SAGE Publications","issue":"6","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK2 BX005600"],"award-info":[{"award-number":["IK2 BX005600"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:p>\n                    Skin injuries are a major healthcare problem that are not well understood or prevented in the critically ill, suggesting that underappreciated variables are contributing. This pilot study tested the hypothesis that perfusion-related factors contribute to skin injuries diagnosed as hospital-acquired pressure injuries (HAPIs). A total of 533 adult patients were followed over 2574 critical care days (mean age 62.4, standard deviation (SD) 14.3 years, mean body mass index 30.4 (SD 7.4) kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    , 36.4% female). This was a secondary analysis of prospective, non-randomised clinical data from an intensive care unit at a large urban teaching hospital. Factors related to perfusion, specifically two or more infusions of vasopressors\/inotropes, temporary mechanical circulatory support (MCS), extracorporeal membrane oxygenation, and durable MCS, were analysed to determine whether they were more strongly associated with HAPIs than immobility due to prolonged mechanical ventilation (&gt;72\u2009h) or operating room time (&gt;6\u2009h). Patients diagnosed with a HAPI had a statistically significant higher risk of being exposed to variables related to perfusion and immobility ( P\u2009&lt;\u20090.05 for each variable). Perfusion-related variables, except durable MCS, had a larger effect on skin breakdown (number needed to harm (NNH) 4\u201310) than immobility-associated variables (NNH 12\u201317). The finding that perfusion-related variables predicted HAPIs may warrant consideration of alternative diagnoses, such as skin failure due to impaired perfusion as a pathophysiological process that occurs concurrently with multisystem organ failure. Differentiation of skin injuries primarily from circulatory malfunction, rather than external pressure, may guide the development of more effective treatment and prevention protocols. This pilot study suggests that the contribution of perfusion to skin injuries should be explored further.\n                  <\/jats:p>","DOI":"10.1177\/0310057x241264575","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T05:43:28Z","timestamp":1728711808000},"page":"386-396","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":8,"title":["Skin injury: Associations with variables related to perfusion and pressure"],"prefix":"10.1177","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0889-8567","authenticated-orcid":false,"given":"Christopher J","family":"Roberts","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"},{"name":"Department of Anesthesiology, Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"Popies","sequence":"additional","affiliation":[{"name":"Department of Advanced Practice Nursing, Froedtert Hospital, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abrahim N","family":"Razzak","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"},{"name":"Department of Anesthesiology, Zablocki Veterans Affairs Medical Center, Milwaukee, WI 53295, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Fang","sequence":"additional","affiliation":[{"name":"Institute for Health and Equity, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavio A","family":"Falcucci","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA"},{"name":"Current Affiliation: Department of Anesthesiology, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Pearson","sequence":"additional","affiliation":[{"name":"Department of Surgery, Division of Cardiothoracic Surgery, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Szabo","sequence":"additional","affiliation":[{"name":"Institute for Health and Equity, Division of Biostatistics, Medical College of Wisconsin, Milwaukee, WI 53226, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"bibr1-0310057X241264575","first-page":"20","volume":"22","author":"Graves N","year":"2014","journal-title":"Wound Pract 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