{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:03:21Z","timestamp":1787742201356,"version":"build-2784847793"},"reference-count":35,"publisher":"SAGE Publications","issue":"4_suppl","license":[{"start":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T00:00:00Z","timestamp":1742947200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:p>\n                    James Young Simpson\u2019s\n                    <jats:italic>Notice of a New Anaesthetic Agent<\/jats:italic>\n                    is a rare pamphlet of which three copies have hitherto been documented. Two of the three known copies were inscribed by Simpson with the words \u2018proof copy\u2019. A fourth copy of the pamphlet, also inscribed with the words \u2018proof copy\u2019, has been identified. Although regarded by Simpson as a proof copy, there is previously unreported evidence that the pamphlet was advertised by the publisher on 12 November 1847, published on 13 November 1847, and sold on that day by booksellers in Edinburgh. Thus, the\n                    <jats:italic>Notice<\/jats:italic>\n                    pamphlet was the first published report of the use of chloroform as an anaesthetic agent. The pamphlet was issued 2 or 3 days before the well-known revised edition bearing the title\n                    <jats:italic>Account of a New Anaesthetic Agent<\/jats:italic>\n                    , and one week before the publication of Simpson\u2019s papers on chloroform in\n                    <jats:italic>The Lancet<\/jats:italic>\n                    and the\n                    <jats:italic>Medical Times<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1177\/0310057x241285167","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T17:41:49Z","timestamp":1743010909000},"page":"17-26","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":1,"title":["James Young Simpson\u2019s\n                    <i>Notice of a New Anaesthetic Agent<\/i>\n                    : The first pamphlet on chloroform"],"prefix":"10.1177","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-0779","authenticated-orcid":false,"given":"Rajesh P","family":"Haridas","sequence":"first","affiliation":[{"name":"Retired Anaesthetist, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2025,3,26]]},"reference":[{"key":"e_1_3_3_2_2","first-page":"202","volume-title":"Memoir of Sir James Young Simpson, Bart","author":"Duns J.","year":"1873","unstructured":"Duns J. Memoir of Sir James Young Simpson, Bart. Edinburgh: Edmonston and Douglas, 1873, p. 202."},{"key":"e_1_3_3_3_2","first-page":"449","article-title":"Session XXVII","volume":"8","author":"Medico-Chirurgical Society of Edinburgh","year":"1847","unstructured":"Medico-Chirurgical Society of Edinburgh. Session XXVII. Monthly J Med Sci 1847; 8: 449\u2013454.","journal-title":"Monthly J Med Sci"},{"key":"e_1_3_3_4_2","first-page":"7","volume-title":"Notice of a New Anaesthetic Agent, as a Substitute for Sulphuric Ether in Surgery and Midwifery","author":"Simpson JY.","year":"1847","unstructured":"Simpson JY. Notice of a New Anaesthetic Agent, as a Substitute for Sulphuric Ether in Surgery and Midwifery. Edinburgh: Sutherland and Knox, 1847, p. 7."},{"key":"e_1_3_3_5_2","volume-title":"Account of a New Anaesthetic Agent, as a Substitute for Sulphuric Ether in Surgery and Midwifery","author":"Simpson JY.","year":"1847","unstructured":"Simpson JY. Account of a New Anaesthetic Agent, as a Substitute for Sulphuric Ether in Surgery and Midwifery. Edinburgh: Sutherland and Knox; and London: Samuel Highley, 1847."},{"key":"e_1_3_3_6_2","first-page":"72","volume-title":"The Centennial of Surgical Anesthesia; an Annotated Catalogue of Books and Pamphlets Bearing on the Early History of Surgical Anesthesia, Exhibited at the Yale Medical Library, October 1946","author":"Fulton JF","year":"1946","unstructured":"Fulton JF, Stanton ME. The Centennial of Surgical Anesthesia; an Annotated Catalogue of Books and Pamphlets Bearing on the Early History of Surgical Anesthesia, Exhibited at the Yale Medical Library, October 1946. New York: Henry Schuman, 1946, pp. 72\u201375."},{"key":"e_1_3_3_7_2","first-page":"80","volume-title":"The Heritage of Anesthesia. Patrick Sim\u2019s Annotated Bibliography of the Rare Book Collection of the Wood Library-Museum of Anesthesiology","author":"Sim P.","year":"2012","unstructured":"Sim P. The Heritage of Anesthesia. Patrick Sim\u2019s Annotated Bibliography of the Rare Book Collection of the Wood Library-Museum of Anesthesiology. Caton D, McGoldrick KE, Snider P, Reilly FA (eds). Park Ridge, IL: Wood Library-Museum of Anesthesiology, 2012, pp. 80\u201381."},{"key":"e_1_3_3_8_2","first-page":"149","volume-title":"A Catalogue of Books Illustrating the History of Medicine and Science","author":"Bibliotheca Osleriana","year":"1929","unstructured":"Bibliotheca Osleriana. A Catalogue of Books Illustrating the History of Medicine and Science. Oxford: Clarendon Press, 1929, p. 149."},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1445-2197.1947.tb05474.x"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5706.414"},{"key":"e_1_3_3_11_2","first-page":"903","article-title":"J. Y. Simpson\u2019s early articles on chloroform","volume":"62","author":"Cranefield PF.","year":"1986","unstructured":"Cranefield PF. J. Y. Simpson\u2019s early articles on chloroform. Bull NY Acad Med 1986; 62: 903\u2013909.","journal-title":"Bull NY Acad Med"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1622.2000.01986.x"},{"key":"e_1_3_3_13_2","first-page":"645","volume-title":"The History of Anaesthesia \u2013 Proceedings of the Sixth International Symposium on the History of Anaesthesia","author":"Newson AJ.","year":"2007","unstructured":"Newson AJ. A role for a rarely acknowledged pamphlet dated 12 November 1847. In: Drury PME, et\u00a0al. (eds). The History of Anaesthesia \u2013 Proceedings of the Sixth International Symposium on the History of Anaesthesia. Reading: Conservatree, 2007, pp. 645\u2013651."},{"key":"e_1_3_3_14_2","first-page":"215","volume-title":"Memoir of Sir James Young Simpson, Bart","author":"Duns J.","year":"1873","unstructured":"Duns J. Memoir of Sir James Young Simpson, Bart. Edinburgh: Edmonston and Douglas, 1873, pp. 215\u2013216."},{"key":"e_1_3_3_15_2","volume-title":"Chloroform, the New Agent for Producing Insensibility to Pain by Inhalation","author":"Waldie D.","year":"1847","unstructured":"Waldie D. Chloroform, the New Agent for Producing Insensibility to Pain by Inhalation. Liverpool: Smith, Rogerson and Co., 1847."},{"key":"e_1_3_3_16_2","first-page":"1153","article-title":"The discovery of chloroform","volume":"40","year":"1847","unstructured":"The discovery of chloroform. London Med Gazette 1847; 40: 1153.","journal-title":"London Med Gazette"},{"key":"e_1_3_3_17_2","volume-title":"The True Story of the Introduction of Chloroform into An\u00e6sthetics: Being the Original Account Given of it in 1847; and a Re-statement in 1870, by David Waldie, \u2026, with Remarks by George Waldie","author":"Waldie D","year":"1870","unstructured":"Waldie D, Waldie G. The True Story of the Introduction of Chloroform into An\u00e6sthetics: Being the Original Account Given of it in 1847; and a Re-statement in 1870, by David Waldie, \u2026, with Remarks by George Waldie. Linlithgow: George Waldie; and Edinburgh: Oliver & Boyd, 1870."},{"key":"e_1_3_3_18_2","first-page":"201","article-title":"Chloroform, the new agent for producing insensibility to pain by inhalation","volume":"3","author":"Waldie D.","year":"1848","unstructured":"Waldie D. Chloroform, the new agent for producing insensibility to pain by inhalation. Pharmaceut Times 1848; 3: 201\u2013203.","journal-title":"Pharmaceut Times"},{"key":"e_1_3_3_19_2","first-page":"571","article-title":"St. Bartholomew\u2019s Hospital. Surgical cases treated at this hospital","volume":"50","author":"Coote H.","year":"1847","unstructured":"Coote H. St. Bartholomew\u2019s Hospital. Surgical cases treated at this hospital. Lancet 1847; 50: 571\u2013572. doi:10.1016\/S0140-6736(02)87482-7","journal-title":"Lancet"},{"key":"e_1_3_3_20_2","first-page":"22","volume-title":"On Chloroform and Other Anaesthetics: Their Action and Administration","author":"Snow J.","year":"1858","unstructured":"Snow J. On Chloroform and Other Anaesthetics: Their Action and Administration. Richardson BW (ed.). London: John Churchill, 1858, p. 22."},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)59240-X"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/1.4.149"},{"key":"e_1_3_3_23_2","unstructured":"North British Daily Mail [Lanarkshire Scotland]. 12 November 1847 p. 2."},{"key":"e_1_3_3_24_2","unstructured":"The Scotsman [Midlothian Scotland]. 13 November 1847 p. 3."},{"key":"e_1_3_3_25_2","unstructured":"The Scotsman [Midlothian Scotland]. 17 November 1847 p. 1."},{"key":"e_1_3_3_26_2","unstructured":"North British Daily Mail [Lanarkshire Scotland]. 20 November 1847 p. 2."},{"key":"e_1_3_3_27_2","first-page":"656","article-title":"Discovery of a new anaesthetic agent more efficient than sulphuric ether","volume":"11","author":"Simpson JY.","year":"1847","unstructured":"Simpson JY. Discovery of a new anaesthetic agent more efficient than sulphuric ether. Provincial Med Surg J 1847; 11: 656\u2013658. doi:10.1136\/bmj.s1-11.24.656","journal-title":"Provincial Med Surg J"},{"key":"e_1_3_3_28_2","first-page":"169","volume-title":"The Development of Inhalation Anaesthesia","author":"Duncum BM.","year":"1947","unstructured":"Duncum BM. The Development of Inhalation Anaesthesia. London: Oxford University Press for The Wellcome Historical Medical Museum, 1947, p. 169."},{"key":"e_1_3_3_29_2","first-page":"412","article-title":"Sir James Simpson\u2019s introduction of chloroform","volume":"47","author":"Simpson EB.","year":"1894","unstructured":"Simpson EB. Sir James Simpson\u2019s introduction of chloroform. Century Mag 1894; 47: 412\u2013420.","journal-title":"Century Mag"},{"key":"e_1_3_3_30_2","first-page":"60","volume-title":"Sir James Y. Simpson","author":"Simpson EB.","year":"1896","unstructured":"Simpson EB. Sir James Y. Simpson. Edinburgh and London: Oliphant, Anderson & Ferrier, 1896, p. 60."},{"key":"e_1_3_3_31_2","first-page":"627","article-title":"Chloroform in Scotland","volume":"25","author":"Simpson JY.","year":"1852","unstructured":"Simpson JY. Chloroform in Scotland. Med Times Gazette 1852; 25: 627\u2013628.","journal-title":"Med Times Gazette"},{"key":"e_1_3_3_32_2","first-page":"1","article-title":"A reply to Dr. Jacob Bigelow\u2019s second letter","volume":"2","author":"Simpson JY.","year":"1870","unstructured":"Simpson JY. A reply to Dr. Jacob Bigelow\u2019s second letter. J Gynecol Soc Boston 1870; 2(Suppl.): 1\u201319.","journal-title":"J Gynecol Soc Boston"},{"key":"e_1_3_3_33_2","first-page":"236","volume-title":"Memoir of Sir James Young Simpson, Bart","author":"Duns J.","year":"1873","unstructured":"Duns J. Memoir of Sir James Young Simpson, Bart. Edinburgh: Edmonston and Douglas, 1873, pp. 236\u2013246."},{"key":"e_1_3_3_34_2","unstructured":"New anaesthetic agent \u2013 ether superseded. 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