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We present a case of a 70-year-old man with prekallikrein deficiency who underwent endovascular aortic repair and required intraoperative anticoagulation control. Intraoperative anticoagulation with heparin and protamine was successfully managed using the activated clotting time measurements after preoperative administration of two units of fresh frozen plasma for prekallikrein replenishment. Preoperative prekallikrein replenishment by fresh frozen plasma administration contributed to safe intraoperative anticoagulation management.<\/jats:p>","DOI":"10.1177\/0310057x251377323","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T12:01:29Z","timestamp":1761134489000},"page":"168-172","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Coagulation management in endovascular aortic repair in a patient with congenital prekallikrein deficiency: a case report"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-1609-9646","authenticated-orcid":false,"given":"Takero","family":"Iwai","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Aichi Children\u2019s Health and Medical Center, Obu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Yamauchi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kariya Toyota General Hospital, Kariya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8941-5944","authenticated-orcid":false,"given":"Osamu","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Kariya Toyota General Hospital, Kariya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7136-9815","authenticated-orcid":false,"given":"Taiki","family":"Kojima","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Aichi Children\u2019s Health and Medical Center, Obu, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[2025,10,22]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-11-0692"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000313361"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/02676591231211502"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199710000-00038"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1051\/ject\/201446254"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0b013e32830891ab"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.jvca.2005.09.001"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1160\/TH09-09-0673"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.31486\/toj.18.0087"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830190409"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X251377323","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0310057X251377323","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X251377323","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:13:20Z","timestamp":1777367600000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X251377323"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,22]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1177\/0310057X251377323"],"URL":"https:\/\/doi.org\/10.1177\/0310057x251377323","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,22]]}}}