{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T11:25:54Z","timestamp":1793964354461,"version":"4.8.0"},"reference-count":35,"publisher":"SAGE Publications","issue":"3_suppl","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":["journals.sagepub.com"],"crossmark-restriction":true},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:p>In contrast to the public spectacle of the Ether Demonstration in 1846, modern regional anaesthesia had a quiet beginning in 1784. That year, James Moore (1762\u20131860), a Scottish junior surgeon, published the first English book devoted solely to anaesthesia: \u2018A Method of Preventing or Diminishing Pain in Several Operations of Surgery\u2019. Using a purpose-made iron nerve compressor, Moore successfully anaesthetised the lower limb and completed a near-painless below-knee amputation with John Hunter (1728\u20131793). Similarly, he also performed the first brachial plexus anaesthesia, introducing the concept of \u2018plexus anaesthesia\u2019. Beyond this achievement, Moore\u2019s 50-page book covers essential perioperative practices that are still relevant today. With the recent rediscovery of a Moore\u2019s compressor in Scotland by the authors, this paper critically analyses Moore\u2019s contribution. It reframes his narrative through frameworks such as the sociological tipping point, self-experimentation, anatomical analysis and collaboration, challenging the prevailing historical paradigm.<\/jats:p>","DOI":"10.1177\/0310057x261486481","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T12:38:27Z","timestamp":1790426307000},"page":"36-43","update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["James Moore and a quiet beginning of modern regional anaesthesia"],"prefix":"10.1177","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5320-562X","authenticated-orcid":false,"given":"Jun D","family":"Parker","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Portland District Health, Portland, VIC, Australia"},{"name":"School of Medicine, Deakin University, Waurn Ponds, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter M","family":"Reid","sequence":"additional","affiliation":[{"name":"Retired Anaesthetist, Dumbarton, West Dunbartonshire, Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-14002-0"},{"key":"e_1_3_3_3_2","first-page":"21","volume-title":"A short history of anesthesia in Japan","author":"Matsuki A.","year":"2012","unstructured":"Matsuki A. Seishu Hanaoka and his medicine. In: Matsuki A (ed.) A short history of anesthesia in Japan. Hirosaki: Hirosaki University Press, 2012, pp. 21\u201372."},{"key":"e_1_3_3_4_2","volume-title":"Dr John Moore, 1729\u20131802: a life in medicine, travel, and revolution","author":"Fulton HL.","year":"2015","unstructured":"Fulton HL. Dr John Moore, 1729\u20131802: a life in medicine, travel, and revolution. Newark (DE): University of Delaware Press, 2015."},{"key":"e_1_3_3_5_2","unstructured":"Moore J. A method of preventing or diminishing pain in several operations of surgery. London: Printed for T Cadell 1784 (Digitised copy accessible from Wellcome Collection: https:\/\/wellcomecollection.org\/works\/awkh78cp)."},{"key":"e_1_3_3_6_2","first-page":"120","volume-title":"The life of Edward Jenner, M.D., with illustrations of his doctrines, and selections from his correspondence","author":"Baron J.","year":"1838","unstructured":"Baron J. The life of Edward Jenner, M.D., with illustrations of his doctrines, and selections from his correspondence, vol. 2. London: H. Colburn, 1838, pp. 120\u2013125."},{"key":"e_1_3_3_7_2","volume-title":"The history of the small pox","author":"Moore J.","year":"1815","unstructured":"Moore J. The history of the small pox. London: Longman, Hurst, Rees, Orme, and Brown, 1815."},{"key":"e_1_3_3_8_2","volume-title":"The life of Lieutenant-General Sir John Moore","author":"Moore JC.","year":"1834","unstructured":"Moore JC. The life of Lieutenant-General Sir John Moore. 2 vols. London: John Murray, 1834."},{"key":"e_1_3_3_9_2","first-page":"1276","volume-title":"Wien Med Wochenschr","author":"Koller C.","year":"1884","unstructured":"Koller C. Ueber die Verwendung des Cocain zur An\u00e4sthesierung am Auge [On the use of cocaine for anaesthesia of the eye]. Wien Med Wochenschr 1884; 43: 1276\u20131277 (44: 1310\u20131311). German."},{"key":"e_1_3_3_10_2","volume-title":"Del coraggio nelle malattie","author":"Pasta G.","year":"1792","unstructured":"Pasta G. Del coraggio nelle malattie [On courage in illness]. Parma: Bodoni, 1792. Italian."},{"key":"e_1_3_3_11_2","unstructured":"Parker J. Retracing the origin of the brachial plexus blocks: James Moore\u2019s underappreciated contributions to regional anaesthesia in the 18th century and compression anaesthesia Moore\u2019s Compressor before and after. Master\u2019s dissertation University of East Anglia UK 2025."},{"key":"e_1_3_3_12_2","first-page":"849","volume-title":"Druitt\u2019s surgeon\u2019s vade-mecum: a manual of modern surgery","author":"Boyd S.","year":"1887","unstructured":"Boyd S. Means of producing insensibility to pain. In: Boyd S (ed.) Druitt\u2019s surgeon\u2019s vade-mecum: a manual of modern surgery. 12th ed. London: Henry Renshaw, 1887, pp. 849\u2013861.","edition":"12"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199403000-00023"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1177\/14782715241298138"},{"key":"e_1_3_3_15_2","volume-title":"Y\u014dgaku zensho","author":"Sat\u014d T.","year":"1860","unstructured":"Sat\u014d T. Y\u014dgaku zensho [Complete treatise on surgery]. Yamazaki Collection. Tokyo: Juntendo University, c. 1860. Japanese."},{"key":"e_1_3_3_16_2","first-page":"715","volume-title":"A system of surgery: pathological, diagnostic, therapeutic, and operative","author":"Gross SD","year":"1882","unstructured":"Gross SD. A system of surgery: pathological, diagnostic, therapeutic, and operative. 6th ed., vol. 1. 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Researches, chemical and philosophical: chiefly concerning nitrous oxide, or diphlogisticated nitrous air, and its respiration. London: J. Johnson, 1800."},{"key":"e_1_3_3_29_2","unstructured":"Bier A. Cocainization of the spinal cord (Wood Library-Museum of Anesthesiology). In: The history of anesthesiology reprint series: Part 14 \u2013 The introduction of local anesthesia [e-book]. Schaumburg: USA. https:\/\/www.woodlibrarymuseum.org\/e-book\/the-history-of-anesthesiology-reprint-series-part-14-the-introduction-of-local-anesthesia\/ (2025 accessed 9 January 2026)."},{"key":"e_1_3_3_30_2","first-page":"643","article-title":"Hydrochlorate of cocaine","volume":"40","author":"Hall RJ.","year":"1884","unstructured":"Hall RJ. Hydrochlorate of cocaine. NY Med J 1884; 40: 643\u2013644.","journal-title":"NY Med J"},{"key":"e_1_3_3_31_2","unstructured":"Swenson J host. Episode 201: The simplified adductor canal block [podcast]. 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