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Age-dependent pharmacokinetics and pharmacodynamic effects of dexmedetomidine make dosing challenging in neonates, but when used appropriately it can minimise the need for exposure to general anaesthesia, airway instrumentation and mechanical ventilation, all of which are associated with adverse perioperative events in neonates, such as apnoea, bradycardia and prolonged postoperative ventilation.<\/jats:p>","DOI":"10.1177\/0310057x261491550","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:43:24Z","timestamp":1790311404000},"update-policy":"https:\/\/doi.org\/10.1177\/sage-journals-update-policy","source":"Crossref","is-referenced-by-count":0,"title":["Dexmedetomidine, high-flow nasal oxygen and regional anaesthesia for neonatal hand surgery"],"prefix":"10.1177","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2710-7739","authenticated-orcid":false,"given":"Hannah M","family":"Lewis","sequence":"first","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia"},{"name":"Department of Anaesthesia and Pain Medicine, Southern Adelaide Local Health Network, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josephine Alexa","family":"Potter","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia"},{"name":"Department of Plastic and Reconstructive Surgery, Southern Adelaide Local Health Network, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4253-0643","authenticated-orcid":false,"given":"Fiona J","family":"Taverner","sequence":"additional","affiliation":[{"name":"College of Medicine and Public Health, Flinders University, Adelaide, SA, Australia"},{"name":"Department of Anaesthesia and Pain Medicine, Southern Adelaide Local Health Network, Adelaide, SA, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"e_1_3_2_2_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005964"},{"key":"e_1_3_2_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2024.12.038"},{"key":"e_1_3_2_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2021.02.016"},{"key":"e_1_3_2_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(17)30116-9"},{"key":"e_1_3_2_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aew401"},{"key":"e_1_3_2_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.13782"},{"key":"e_1_3_2_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000005232"},{"key":"e_1_3_2_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2009.03133.x"},{"key":"e_1_3_2_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex085"},{"key":"e_1_3_2_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14605"},{"key":"e_1_3_2_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9592.2010.03285.x"},{"key":"e_1_3_2_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.12310"},{"key":"e_1_3_2_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14235"},{"key":"e_1_3_2_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2024.12.021"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X261491550","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/full-xml\/10.1177\/0310057X261491550","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X261491550","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T08:47:08Z","timestamp":1790498828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X261491550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,24]]},"references-count":14,"alternative-id":["10.1177\/0310057X261491550"],"URL":"https:\/\/doi.org\/10.1177\/0310057x261491550","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,24]]},"article-number":"0310057X261491550"}}