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The effects of the administration of a sympathomimetic amine cannot be accurately predicted in a subject. Choice of which sympathomimetic amine to use should be determined on the basis of data obtained in relevant clinical circumstances, but the dose should always be titrated against the effect in each individual.<\/jats:p>\n                  <jats:p>\n                    It is interesting that adrenaline, \u201cthe original autonomic drug\u201d with its \u201cvenerable history\u201d,\n                    <jats:sup>56<\/jats:sup>\n                    is still a first line drug in many of the situations for which it was being prescribed in 1907. It is the drug of first choice in anaphylactic reactions and for severe allergic bronchospasm, and is widely used as a vasoconstrictor in surgery and with local anaesthetic agents. 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