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In man the drug has a significant action at the neuromuscular junction, but has little effect on the autonomic nervous system or muscle (smooth, skeletal, or cardiac) although such actions have been demonstrated in animals.<\/jats:p>\n                  <jats:p>It may be clinically useful in the reversal of nondepolariser blockade and a role in antibiotic associated block has been proposed. It may be used effectively as an analeptic agent. It appears to be a useful therapeutic agent in myasthenia gravis and Eaton Lambert syndrome, although of limited use in botulism.<\/jats:p>\n                  <jats:p>Its effects on the central nervous system are considerable. These account for the major side effects of the drug which include tremor, excitability and convulsions.<\/jats:p>","DOI":"10.1177\/0310057x8201000205","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T09:26:23Z","timestamp":1547457983000},"page":"120-126","source":"Crossref","is-referenced-by-count":31,"title":["4-Aminopyridine \u2014 A Review"],"prefix":"10.1177","volume":"10","author":[{"given":"N.","family":"Soni","sequence":"first","affiliation":[{"name":"Department of Anaesthesia, Westmead Centre, Parramatta, N.S.W."},{"name":"Department of Anaesthesia, Westmead Centre, Westmead, N.S.W."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Kam","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia, Westmead Centre, Parramatta, N.S.W."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1982,5,1]]},"reference":[{"key":"bibr1-0310057X8201000205","author":"Glover W.E.","journal-title":"Gen Pharmacol"},{"key":"bibr2-0310057X8201000205","doi-asserted-by":"publisher","DOI":"10.1038\/icb.1958.39"},{"key":"bibr3-0310057X8201000205","first-page":"139","volume":"4","author":"Stoyanov E.","year":"1976","journal-title":"Anaesth Resus Intens Ther"},{"key":"bibr4-0310057X8201000205","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90378-7"},{"key":"bibr5-0310057X8201000205","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(76)90202-8"},{"key":"bibr6-0310057X8201000205","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/53.6.567"},{"key":"bibr7-0310057X8201000205","first-page":"21","volume-title":"Medico Biologic information","author":"Stoyanov E.","year":"1975"},{"key":"bibr8-0310057X8201000205","first-page":"79","volume":"28","author":"Bowman W.","journal-title":"J. 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