{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T10:30:25Z","timestamp":1790505025634,"version":"4.1.0"},"reference-count":15,"publisher":"SAGE Publications","issue":"3","license":[{"start":{"date-parts":[[1983,8,1]],"date-time":"1983-08-01T00:00:00Z","timestamp":428544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1983,8]]},"abstract":"<jats:p>Although anaphylactoid reactions to muscle-relaxant drugs are now well recognised, there has been no general agreement on the mechanism(s) underlying the responses.<\/jats:p>\n                  <jats:p>\n                    By covalently coupling alcuronium and tubocurarine to a solid phase carrier and using the resultant complexes in radioimmunoassay experiments with patients\u2019 sera and\n                    <jats:sup>125<\/jats:sup>\n                    I-anti-human IgE, we have found high levels of drug-specific IgE antibodies in the sera of some subjects who reacted to these muscle relaxants.\n                  <\/jats:p>\n                  <jats:p>These results provide important supporting evidence that, in some patients at least, lifethreatening anaphylactoid reactions to muscle-relaxant drugs are mediated by drug-specific IgE antibodies.<\/jats:p>","DOI":"10.1177\/0310057x8301100302","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T09:33:10Z","timestamp":1547458390000},"page":"194-197","source":"Crossref","is-referenced-by-count":70,"title":["Detection of Serum IgE Antibodies that React with Alcuronium and Tubocurarine after Lifethreatening Reactions to Muscle-relaxant Drugs"],"prefix":"10.1177","volume":"11","author":[{"given":"B. A.","family":"Baldo","sequence":"first","affiliation":[{"name":"Rolling Institute of Medical Research, and Intensive Therapy Unit, Royal North Shore Hospital, Sydney, New South Wales"},{"name":"Senior Research Fellow in Allergic Diseases."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. McD.","family":"Fisher","sequence":"additional","affiliation":[{"name":"Rolling Institute of Medical Research, and Intensive Therapy Unit, Royal North Shore Hospital, Sydney, New South Wales"},{"name":"Head, Intensive Therapy Unit."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"179","published-online":{"date-parts":[[1983,8,1]]},"reference":[{"key":"bibr1-0310057X8301100302","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/48.2.57"},{"key":"bibr2-0310057X8301100302","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X8100900304"},{"key":"bibr3-0310057X8301100302","first-page":"65","volume-title":"Monographs in Anaesthesiology No. 8. 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