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Although there was considerable variation among children in the concentration and time-course of metabolite exhalation, exhaled concentrations of these metabolites were of a similar magnitude to those reported in adults. This result suggests that the lower incidence of halothane hepatitis in children compared with adults is not due to a poor ability to metabolise halothane by the reductive pathway.<\/jats:p>","DOI":"10.1177\/0310057x8401200401","type":"journal-article","created":{"date-parts":[[2019,1,22]],"date-time":"2019-01-22T06:44:17Z","timestamp":1548139457000},"page":"293-295","source":"Crossref","is-referenced-by-count":6,"title":["Reductive Metabolism of Halothane in Children"],"prefix":"10.1177","volume":"12","author":[{"given":"John L.","family":"Plummer","sequence":"first","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, South Australia and Department of Anaesthesia, Adelaide Children's Hospital Inc., North Adelaide, South Australia"},{"name":"Senior Staff Anaesthetist, Adelaide Children's Hospital Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan H.","family":"Van der Walt","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, South Australia and Department of Anaesthesia, Adelaide Children's Hospital Inc., North Adelaide, South Australia"},{"name":"Senior Staff Anaesthetist, Adelaide Children's Hospital Inc."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Cousins","sequence":"additional","affiliation":[{"name":"Department of Anaesthesia and Intensive Care, Flinders Medical Centre, Bedford Park, South Australia and Department of Anaesthesia, Adelaide Children's Hospital Inc., North Adelaide, South Australia"},{"name":"Professor and Chairman, Flinders Medical Centre."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1984,11,1]]},"reference":[{"key":"bibr1-0310057X8401200401","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1515\/DMDI.1982.4.1.49","volume":"4","author":"Plummer J.L.","year":"1982","journal-title":"Reviews on Drug Metab Drug Interact"},{"key":"bibr2-0310057X8401200401","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0674-1_44"},{"key":"bibr3-0310057X8401200401","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.280.6225.1197"},{"key":"bibr4-0310057X8401200401","first-page":"237","volume":"38","author":"Wark H.J.","year":"1983","journal-title":"Anaesthesia"},{"key":"bibr5-0310057X8401200401","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1177\/0310057X7700500218","volume":"5","author":"Allen T.H.","year":"1977","journal-title":"Anaesth Intens Care"},{"key":"bibr6-0310057X8401200401","first-page":"480","volume":"45","author":"Pratilas V.","year":"1978","journal-title":"Mt Sinai J Med"},{"key":"bibr7-0310057X8401200401","doi-asserted-by":"publisher","DOI":"10.1177\/0310057X7900700102"},{"key":"bibr8-0310057X8401200401","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-197901000-00002"},{"key":"bibr9-0310057X8401200401","first-page":"331","volume":"52","author":"Gourlay G.K.","year":"1980","journal-title":"Br J Anaesth"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X8401200401","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X8401200401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:06:14Z","timestamp":1777367174000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X8401200401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11]]},"references-count":9,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984,11]]}},"alternative-id":["10.1177\/0310057X8401200401"],"URL":"https:\/\/doi.org\/10.1177\/0310057x8401200401","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,11]]}}}