{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T12:01:06Z","timestamp":1777377666444,"version":"3.51.4"},"reference-count":24,"publisher":"SAGE Publications","issue":"4","license":[{"start":{"date-parts":[[1989,11,1]],"date-time":"1989-11-01T00:00:00Z","timestamp":625881600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/journals.sagepub.com\/page\/policies\/text-and-data-mining-license"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anaesth Intensive Care"],"published-print":{"date-parts":[[1989,11]]},"abstract":"<jats:p>\n                    We measured pulmonary clearance of aerosolised\n                    <jats:sup>99m<\/jats:sup>\n                    technetium-labelled diethylenetriaminepentacetate (\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-DTPA) in thirty-four patients with acute respiratory dysfunction. Results were expressed as a half-time clearance from lung to blood (T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    ). In sixteen non-smoking patients with acute lung injury, clearance was monoexponential, median T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    11, range 4\u201340 min, and in five multi-exponential, median rapid T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    3 min, with a slower median T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    of 18 min (range 2\u20134 and 15\u201331 min respectively). Clearance was significantly (P &lt; 0.0001) more rapid than normal non-smoking subjects previously studied (median T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    70, range 37\u2013182 min). Three smokers with acute lung injury had T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    s of 5, 18 and 22 min, not significantly (P&gt; 0.05) quicker than normal smokers previously studied (median T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    20, range 6\u201373 min). One smoking lung-injured patient had an abnormal multi-exponential\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-DTPA clearance. Four patients with cardiogenic pulmonary oedema had T\n                    <jats:sub>\u00bd<\/jats:sub>\n                    s within the normal range. Repeated measurements made on nine patients with acute lung injury showed that clearance remained abnormally rapid despite improvements in lung radiographic appearance and gas exchange. We conclude that the\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-DTPA technique provides a virtually non-invasive measure of alveolar-capillary barrier dysfunction in non-smoking patients with acute lung injury.\n                  <\/jats:p>","DOI":"10.1177\/0310057x8901700405","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T09:58:24Z","timestamp":1547459904000},"page":"422-432","source":"Crossref","is-referenced-by-count":11,"title":["Pulmonary Clearance of\n                    <sup>99m<\/sup>\n                    Tc-DTPA in the Diagnosis and Evolution of Increased Permeability Pulmonary Oedema"],"prefix":"10.1177","volume":"17","author":[{"given":"M. P.","family":"Barrowcliffe","sequence":"first","affiliation":[{"name":"Division of Anaesthesia, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. G.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Anaesthesia, MRC Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, U.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"179","published-online":{"date-parts":[[1989,11,1]]},"reference":[{"key":"bibr1-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)90168-7"},{"key":"bibr2-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1974.54.3.678"},{"key":"bibr3-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1136\/thx.42.1.1"},{"key":"bibr4-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/45.7.711"},{"key":"bibr5-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90493-6"},{"key":"bibr6-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1988.64.3.1045"},{"key":"bibr7-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198704000-00001"},{"key":"bibr8-0310057X8901700405","first-page":"599","volume":"59","author":"Onwubalili J.K.","year":"1986","journal-title":"Quart J Med"},{"issue":"153","key":"bibr9-0310057X8901700405","first-page":"68","volume":"71","author":"Barrowcliffe M.P.","year":"1987","journal-title":"Eur J Respir Dis"},{"key":"bibr10-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90066-4"},{"key":"bibr11-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1989.66.1.288"},{"key":"bibr12-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198501000-00002"},{"key":"bibr13-0310057X8901700405","first-page":"370","volume":"45","author":"Valimaki M.","year":"1974","journal-title":"Aerosp Med"},{"key":"bibr14-0310057X8901700405","first-page":"233","volume":"134","author":"Griffith D.E.","year":"1986","journal-title":"Am Rev Respir Dis"},{"key":"bibr15-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.4.1242"},{"key":"bibr16-0310057X8901700405","first-page":"A424","volume":"131","author":"Nolop K.B.","year":"1985","journal-title":"Am Rev Respir Dis"},{"key":"bibr17-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6346.931"},{"key":"bibr18-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1983.127.5.590"},{"key":"bibr19-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1984.57.4.1002"},{"key":"bibr20-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-198308000-00002"},{"key":"bibr21-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6271.1183"},{"key":"bibr22-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.3.327"},{"key":"bibr23-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.146.2.6849076"},{"key":"bibr24-0310057X8901700405","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)90923-6"}],"container-title":["Anaesthesia and Intensive Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X8901700405","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.sagepub.com\/doi\/pdf\/10.1177\/0310057X8901700405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T09:08:23Z","timestamp":1777367303000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.sagepub.com\/doi\/10.1177\/0310057X8901700405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,11]]},"references-count":24,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,11]]}},"alternative-id":["10.1177\/0310057X8901700405"],"URL":"https:\/\/doi.org\/10.1177\/0310057x8901700405","relation":{},"ISSN":["0310-057X","1448-0271"],"issn-type":[{"value":"0310-057X","type":"print"},{"value":"1448-0271","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,11]]}}}